In Vitro and In Vivo Antibacterial Activity of T-1220, a New Semisynthetic Penicillin
| Autor: | Taki Hideo, Tai Masaru, I. Saikawa, Yasuo Watanabe, Susumu Mitsuhashi, T. Hayashi, T Yasuda, Yoshikazu Fukuoka, K. Ueo |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Gram-negative bacteria medicine.drug_class Antibiotics Microbial Sensitivity Tests medicine.disease_cause Microbiology Mice Drug Stability Physiological Effects and Microbial Susceptibility Ampicillin medicine Animals Pharmacology (medical) Pharmacology Mice Inbred ICR Bacteria biology Pseudomonas aeruginosa Bacterial Infections Carbenicillin biology.organism_classification Culture Media Penicillin Infectious Diseases Serratia marcescens beta-Lactamase Inhibitors Antibacterial activity medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 12:455-460 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.12.4.455 |
| Popis: | T-1220, sodium 6-[ d -(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonyl-amino)- α-phenylacetamido] penicillanate, is a new semisynthetic penicillin derivative that possesses a broad spectrum of in vitro antibacterial activity against gram-positive and gram-negative bacteria. T-1220 is more effective than carbenicillin (CB-PC) against Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus species, and Serratia marcescens . Addition of human serum to culture media did not significantly alter the antibacterial activity of T-1220. Greater bactericidal activity toward various strains of gram-negative bacteria was demonstrated with T-1220 than with CB-PC. T-1220, like penicillin G, was hydrolyzed by penicillinase, but was sable to a type IV penicillinase produced by P. aeruginosa strains. In vivo antibacterial activities of T-1220, ampicillin (AB-PC), and CB-PC were compared, using systemic infections of mice with P. aeruginosa, K. pneumoniae , and Escherichia coli . The 50% effective doses (milligrams per kilogram) of T-1220 were consistently lower than those of AB-PC and CB-PC. |
| Databáze: | OpenAIRE |
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