Circadian rhythms in leukocyte trafficking
| Autor: | David Druzd, Christoph Scheiermann, Alba de Juan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Leukocyte migration
Immunology Circadian clock CLOCK Proteins Disease Biology Proinflammatory cytokine Immune system ARNTL Transcription Factors/genetics/metabolism Cell Movement Circadian Clocks Leukocyte Trafficking Leukocytes Immunology and Allergy Animals Homeostasis Humans Circadian rhythm Stem Cell Niche Leukocytes/physiology ARNTL Transcription Factors Cell movement Hematopoietic Stem Cells Circadian Rhythm Circadian Clocks/physiology Immune System Diseases/genetics/immunology/metabolism Phenotype Immune System Diseases Circadian Rhythm/physiology CLOCK Proteins/genetics/metabolism |
| Zdroj: | Seminars in Immunopathology, Vol. 36, No 2 (2014) pp. 149-162 |
| ISSN: | 1863-2297 |
| Popis: | A broad range of immunological processes oscillates over the course of a day. Recent findings have identified a molecular basis for the circadian clock in the regulation of the immune system. These rhythms manifest themselves in oscillatory behavior of immune cells and proinflammatory mediators, which causes a time-dependent sensitivity in the reaction to pathogens. This rhythmicity impacts disease manifestations and severity and provides an option for therapy that incorporates chronopharmacological considerations. This review will focus on the current knowledge and relevance of rhythmic immune cell trafficking. It will provide an overview of the molecular clock machinery and its interrelations with leukocyte migration and the immune response. |
| Databáze: | OpenAIRE |
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