Prostate cancer and inflammation: A new molecular imaging challenge in the era of personalized medicine
| Autor: | Virginia Tancredi, Elena Bonanno, Agostino Chiaravalloti, Donata Trivigno, Rita Bonfiglio, Alessandro Mauriello, Nicoletta Urbano, Lucia Anemona, Manuel Scimeca, Simone Facchetti, Giuseppe Santeusanio, Orazio Schillaci |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Molecular imaging Context (language use) Settore MED/08 - Anatomia Patologica 030218 nuclear medicine & medical imaging Management of prostate cancer 03 medical and health sciences Prostate cancer 0302 clinical medicine Settore MED/36 - Diagnostica per Immagini e Radioterapia Prostate Internal medicine medicine Pathology Humans Radiology Nuclear Medicine and imaging Precision Medicine Inflammation business.industry Cancer Prostatic Neoplasms Anatomical pathology medicine.disease Prognosis Personalized medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Positron-Emission Tomography Molecular Medicine Biomarkers business |
| Popis: | The relationship between cancer and inflammation is one of the most important fields for both clinical and translational research. Despite numerous studies reported interesting and solid data about the prognostic value of the presence of inflammatory infiltrate in cancers, the biological role of inflammation in prostate cancer development is not yet fully clarified. The characterization of molecular pathways that connect altered inflammatory response and prostate cancer progression can provide the scientific rationale for the identification of new prognostic and predictive biomarkers. Specifically, the detection of infiltrating immune cells or related-cytokines by histology and/or by molecular imaging techniques could profoundly change the management of prostate cancer patients. In this context, the anatomic pathology and imaging diagnostic teamwork can provide a valuable support for the validation of new targets for diagnosis and therapy of prostate cancer lesions associated to the inflammatory infiltrate. The aim of this review is to summarize the current literature about the role of molecular imaging technique and anatomic pathology in the study of the mutual interaction occurring between prostate cancer and inflammation. Specifically, we reported the more recent advances in molecular imaging and histological methods for the early detection of prostate lesions associated to the inflammatory infiltrate. |
| Databáze: | OpenAIRE |
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