Human Protease-Activated Receptor 1 Expression in Malignant Epithelia
| Autor: | Yong-Jun Yin, Tamar Peretz, Myriam Maoz, Beatrice Uziely, Rachel Bar-Shavit, Sharona Even-Ram, Zaidoun Salah, Sorina Grisaru-Granovsky, Irit Cohen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Vascular Endothelial Growth Factor A
Integrins Pathology medicine.medical_specialty Angiogenesis Placenta Breast Neoplasms Biology medicine.disease_cause Mice Pregnancy In vivo Morphogenesis medicine Animals Humans Neoplasm Invasiveness Receptor PAR-1 Receptors Vitronectin Breast Neoplasm Metastasis Receptor Cytoskeleton Mice Knockout Matrigel Neovascularization Pathologic Thrombin Epithelial Cells Oligonucleotides Antisense Phenotype Epithelium Cell biology Protease-Activated Receptor 1 medicine.anatomical_structure cardiovascular system Female Cardiology and Cardiovascular Medicine Carcinogenesis Cell Division |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 23:940-944 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.0000066878.27340.22 |
| Popis: | While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands. |
| Databáze: | OpenAIRE |
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