Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease
| Autor: | Ho Sang Ryu, Yeon Seok Seo, Hoon Jai Chun, Eun Suk Jung, Hyung Joon Yim, Bora Keum, Yoon Tae Jeen, Nam Hee Won, Soon Ho Um, Hanna Yoo, Yong Dae Kwon, Chang Duck Kim, Sanghoon Park, Yong Sik Kim, Han Hyo Lee |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Pathology Chronic liver disease Gastroenterology Chronic Liver Disease Liver disease Fibrosis Predictive Value of Tests Internal medicine medicine Humans alpha-Macroglobulins Prospective Studies Hyaluronic Acid medicine.diagnostic_test Haptoglobins Gastroenterology & Hepatology business.industry Liver Diseases Fatty liver General Medicine Hepatitis C Middle Aged medicine.disease Hepatitis B Fatty Liver ROC Curve Liver biopsy Predictive value of tests Chronic Disease Female Original Article Biological Markers Hepatic fibrosis business Biomarkers |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 |
| Popis: | The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined asor =F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, alpha2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, alpha2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease. |
| Databáze: | OpenAIRE |
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