Sensory Neurons that Detect Stretch and Nutrients in the Digestive System
| Autor: | Stephen D. Liberles, David E. Strochlic, Erika K. Williams, Bradford B. Lowell, Rui B. Chang, Benjamin D. Umans |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Serotonin medicine.medical_specialty Sensory Receptor Cells Sensory system Optogenetics Biology Distension Article Glucagon-Like Peptide-1 Receptor General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled Mice 03 medical and health sciences Internal medicine Neural Pathways medicine Humans Animals Neurons Afferent Neurons Gastrointestinal Physiology Stomach digestive oral and skin physiology Vagus Nerve Ganglion Vagus nerve 030104 developmental biology medicine.anatomical_structure Endocrinology Ganglia Neuron Gastrointestinal Motility Neuroscience |
| Zdroj: | Cell. 166:209-221 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2016.05.011 |
| Popis: | Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormones and organ distension. Here, we investigate the molecular diversity of vagal sensory neurons and their roles in sensing gastrointestinal inputs. Genetic approaches allowed targeted investigation of gut-to-brain afferents involved in homeostatic responses to ingested nutrients (GPR65 neurons) and mechanical distension of the stomach and intestine (GLP1R neurons). Optogenetics, in vivo ganglion imaging, and genetically guided anatomical mapping provide direct links between neuron identity, peripheral anatomy, central anatomy, conduction velocity, response properties in vitro and in vivo, and physiological function. These studies clarify the roles of vagal afferents in mediating particular gut hormone responses. Moreover, genetic control over gut-to-brain neurons provides a molecular framework for understanding neural control of gastrointestinal physiology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|