The association of peroxisome proliferator-activated receptor α with diabetic retinopathy, and additional gene–obesity interaction in Chinese type 2 diabetes mellitus patients

Autor: Yixuan Zhao, Yan Cheng, Yan Zhang, Shounan Qi, Shurong Wang, Chenguang Wang
Rok vydání: 2016
Předmět:
Adult
Male
China
medicine.medical_specialty
Genotype
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Asian People
Internal medicine
Odds Ratio
Humans
Medicine
Genetic Predisposition to Disease
PPAR alpha
030212 general & internal medicine
Alleles
Abdominal obesity
Aged
Diabetic Retinopathy
Nutrition and Dietetics
Multifactor dimensionality reduction
business.industry
Homozygote
Type 2 Diabetes Mellitus
Epistasis
Genetic
Odds ratio
Diabetic retinopathy
medicine.disease
Obesity
Minor allele frequency
Logistic Models
Diabetes Mellitus
Type 2
Case-Control Studies
Obesity
Abdominal
Female
Gene-Environment Interaction
medicine.symptom
business
Zdroj: Obesity Research & Clinical Practice. 10:S103-S109
ISSN: 1871-403X
DOI: 10.1016/j.orcp.2015.11.002
Popis: Summary Aims To investigate the impact of peroxisome proliferator-activated receptor α (PPAR α) SNPs and gene–obesity interaction on diabetic retinopathy (DR) susceptibility in a Chinese Han population. Methods A total of 812 patients (373men, 439 women) with type 2 diabetes mellitus (T2DM), with a mean age of 53.3±14.0 years old, were selected, including 402 diabetic retinopathy patients and 410 controls. Three single nucleotide polymorphisms (SNPs) were selected for genotyping in the case–control study: rs4253778, rs135539 and rs1800206. Generalised multifactor dimensionality reduction (GMDR) and logistic regression model was used to examine the association and interaction between SNP and obesity on DR, odds ratio (OR) and 95% confident interval (95%CI) were calculated. Results The carriers of homozygous mutant of rs1800206 SNP revealed decreased DR risk than those with wild-type homozygotes, OR (95%CI) was 0.78 (0.66–0.94). GMDR analysis indicated a significant two-locus model ( p =0.0107) involving rs1800206 and abdominal obesity, indicating a potential interaction among rs1800206 and abdominal obesity. Overall, the two-locus models had a cross-validation consistency of 10 of 10, and had the testing accuracy of 60.72%. We also found that subjects with abdominal obesity and LV or VV genotype have lowest DR risk, compared to subjects with normal WC and LL genotype, OR (95%CI) was 0.39 (0.30–0.74), after covariates adjustment. Conclusions Our results support an important association between rs1800206 minor allele of PPAR α and DR, and the interaction analysis also shown a combined effect of Leu162 allele-abdominal obesity interaction on DR.
Databáze: OpenAIRE
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