Effects of Arsenic (V)-Chromium (III) Interaction on Plasma Glucose and Cholesterol Levels in Growing Rats
| Autor: | M.J. González, M. V. Aguilar, M.C. Martínez-Para |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Blood Glucose
Chromium Male inorganic chemicals Absorption (pharmacology) medicine.medical_specialty Medicine (miscellaneous) chemistry.chemical_element Growth Arsenic chemistry.chemical_compound Internal medicine Weight Loss Blood plasma medicine Animals Drug Interactions Rats Wistar Lung Plasma glucose Nutrition and Dietetics Cholesterol Myocardium Organ Size Rats Protein catabolism Endocrinology Liver chemistry Toxicity Hair Nuclear chemistry |
| Zdroj: | Annals of Nutrition and Metabolism. 41:189-195 |
| ISSN: | 1421-9697 0250-6807 |
| DOI: | 10.1159/000177995 |
| Popis: | Recent studies have demonstrated interaction between arsenic (As) and chromium (Cr) affecting absorption and/or protein catabolism. In the present study the possible effects of As(V)/Cr(III) interaction on growth rate, organ weight, and the two main organic functions of Cr, i.e., regulation of plasma glucose levels and total plasma cholesterol levels, was examined in weaned male Wistar rats. The diet of 20 rats was supplemented with 5 micrograms of As(V) and/or Cr(III) per gram of food for 10 weeks. As/Cr interaction did not significantly affect growth rates on organ weight:body weight ratios but did decrease total plasma cholesterol levels, though the decrease was not as pronounced as in the group supplemented with Cr alone (p0.1). Since supplementation with As(V) produced the opposite effect (96.83 vs. 47.27) (p0.01), the combined use of As and Cr may prove beneficial in cases of chronic As(V) intoxication. Supplementation treatment with As(V) and Cr(III) combined had no significant effect on glucose levels, because though As(V) affects Cr tissue levels and thus alters the effect of Cr on plasma cholesterol levels, individual effects of As(V) and Cr(III) are similar, and hence basal glucose levels are unaffected. |
| Databáze: | OpenAIRE |
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