Discovery of Phenolic Matrix Metalloproteinase Inhibitors by Peptide Microarray for Osteosarcoma Treatment
| Autor: | Minghong Jian, Xudong Sun, Guorong Cheng, Hua Zhang, Xiaotong Li, Fengrui Song, Zhiqiang Liu, Zhenxin Wang |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Osteosarcoma Biological Products Organic Chemistry Pharmaceutical Science Antineoplastic Agents Bone Neoplasms Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases Analytical Chemistry Molecular Docking Simulation Mice Matrix Metalloproteinase 9 Complementary and alternative medicine Matrix Metalloproteinase 13 Drug Discovery Animals Molecular Medicine Peptides |
| Zdroj: | Journal of Natural Products. 85:2424-2432 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.2c00626 |
| Popis: | Because of the abnormal upregulation of matrix metalloproteinase (MMP) activities in tumors, MMP inhibitors (MMPIs) are validated anticancer drug candidates. We identified several MMPIs including mangiferin as an MMP-9 inhibitor with a half maximal inhibitory concentration (IC |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|