Serum anti-Lewis X antibody is associated with VacA seropositivity but not atrophic gastritis in patients with Helicobacter pylori infection
| Autor: | Fumihiko Kurimoto, Masanori Tanaka, Tadashi Shimoyama, Shinsaku Fukuda, Naoto Sugawara, Akihiro Munakata |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Gastritis
Atrophic Atrophic gastritis Spirillaceae Lewis X Antigen Enzyme-Linked Immunosorbent Assay Antibodies Helicobacter Infections Bacterial Proteins Antigen Gastric mucosa medicine Humans CagA Antigens Bacterial Helicobacter pylori Hepatology biology business.industry Gastroenterology bacterial infections and mycoses biology.organism_classification medicine.disease Antibodies Anti-Idiotypic medicine.anatomical_structure Immunoglobulin G Immunology biology.protein Antibody Gastritis medicine.symptom business |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 13:227-231 |
| ISSN: | 0954-691X |
| Popis: | OBJECTIVES Lipopolysaccharides of Helicobacter pylori have an antigenic structure that mimics Lewis X occurring in gastric mucosa. The pathogenic role of antigenic mimicry in H. pylori-induced gastritis has been of recent interest. The aim of this study was to examine the relevance of anti-Lewis X antibody in the development of atrophic gastritis in H. pylori infection. METHODS A total of 72 patients were studied. Serum samples were collected to measure IgG antibodies to H. pylori, CagA, VacA and Lewis X. Biopsy specimens were obtained from the antrum and the corpus to examine the grade and the type of atrophic gastritis. RESULTS Mean anti-Lewis X antibody titres were higher in 38 VacA-seropositive patients than in 13 seronegative patients (P < 0.05). The difference was not significant between patients with diffuse-type atrophic gastritis and those with multi-focal type. No significant correlation was observed between the titre of anti-Lewis X antibody and the grade of glandular atrophy, whereas CagA seropositivity was associated with glandular atrophy. CONCLUSIONS Anti-Lewis X antibody may play a role in persistent gastric inflammation, particularly in VacA-seropositive H. pylori infection. However, anti-Lewis X antibody does not seem itself to be associated with atrophic gastritis in patients with H. pylori infection. |
| Databáze: | OpenAIRE |
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