High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology
| Autor: | Kiley Thueson, Gina Carrion, Justin C. Havird, Gerald P. Maeda, Samantha Rabinowitz, Rachel Nix, Ryan J. Weaver, Erik N. K. Iverson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Alternative oxidase Mutation rate Physiology Oxidative phosphorylation 01 natural sciences Genome DNA Mitochondrial Evolution Molecular Mitochondrial Proteins 03 medical and health sciences Mutation Rate Respiration Silene Mitochondrial mutation 030304 developmental biology Genetics 0303 health sciences biology biology.organism_classification Agricultural and Biological Sciences (miscellaneous) Mitochondria Mutation General Agricultural and Biological Sciences Genome Plant 010606 plant biology & botany |
| Zdroj: | Biol Lett |
| Popis: | Mitochondrial (mt) respiration depends on proteins encoded both by the mitochondrial and nuclear genomes. Variation in mt-DNA mutation rates exists across eukaryotes, although the functional consequences of elevated mt mutation rates in some lineages remain underexplored. In the angiosperm genus Silene , closely related, ecologically similar species have either ‘fast' or ‘slow' mt-DNA mutation rates. Here, we investigated the functional consequences of elevated mt-DNA mutation rates on mt respiration profiles of Silene mitochondria. Overall levels of respiration were similar among Species. Fast species had lower respiration efficiency than slow species and relied up to 48% more on nuclear-encoded respiratory enzymes alternative oxidase (AOX) and accessory dehydrogenases (DHex), which participate in stress responses in plants. However, not all fast species showed these trends. Respiratory profiles of some enzymes were correlated, most notably AOX and DHex. We conclude that subtle differences in mt physiology among Silene lineages with dramatically different mt mutation rates may underly similar phenotypes at higher levels of biological organization, betraying the consequences of mt mutations. |
| Databáze: | OpenAIRE |
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