Scale-free dynamics of somatic adaptability in immune system
| Autor: | Osamu Narikiyo, Shiro Saito |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Statistics and Probability
Self-organized criticality Scale (ratio) Adaptive immune system media_common.quotation_subject FOS: Physical sciences Biology Models Biological General Biochemistry Genetics and Molecular Biology Adaptability Epigenesis Genetic Immune system Cell Behavior (q-bio.CB) Epigenetic landscape Immune Tolerance Physics - Biological Physics Robustness Cellular Senescence media_common Feedback Physiological Applied Mathematics Scale-free network Robustness (evolution) General Medicine Immunosenescence biochemical phenomena metabolism and nutrition Acquired immune system Living systems Biological Physics (physics.bio-ph) Modeling and Simulation Immune System FOS: Biological sciences Immunology Quantitative Biology - Cell Behavior bacteria Neuroscience Immunologic Memory |
| Zdroj: | BioSystems. 103(3):420-424 |
| ISSN: | 0303-2647 |
| Popis: | The long-time dynamics of somatic adaptability in immune system is simulated by a simple physical model. The immune system described by the model exhibits a scale free behavior as is observed in living systems. The balance between the positive and negative feedbacks of the model leads to a robust immune system where the positive one corresponds to the formation of memory cells and the negative one to immunosuppression. Also the immunosenescence of the system is discussed based on the time-dependence of the epigenetic landscape of the adaptive immune cells in the shape space. Comment: 14 pages, 8 figures |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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