On the etiology of cardiovascular diseases: A new framework for understanding literature results
| Autor: | António Heitor Reis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty etiology Cell Myocardial Infarction Inflammation Context (language use) Fatty Acids Nonesterified 030204 cardiovascular system & hematology Biology Cardiovascular Death Sudden 03 medical and health sciences 0302 clinical medicine Thromboembolism medicine Humans 030212 general & internal medicine Myocardial infarction Stroke Micelles Ions chemistry.chemical_classification Vesicle Fatty Acids Fatty acid General Medicine Carbon Dioxide Hydrogen-Ion Concentration Models Theoretical medicine.disease Plaque Atherosclerotic medicine.anatomical_structure chemistry Cardiovascular Diseases Etiology Calcium Stress Mechanical medicine.symptom Shear Strength |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2016.04.046 |
| Popis: | The interpretative framework presented here provides a rationale for many well-known features of cardiovascular diseases. Prolonged acidemia with high blood levels of free fatty acids is proposed to shape the basic context for formation of fatty acid micelles and vesicles with an acidic core that fuse with the endothelia, disrupt vital cell processes, and initiate atherosclerotic plaque formation. It offers an explanation for the distributed localization of atherosclerotic lesions, and how mild cases of occurrence of fatty acids vesicles formed within the heart and the arteries close to the heart may cause such lesions. It provides a rationale for how acute events, namely heart attacks and strokes, may arise from stormy development of fatty acid vesicles within the heart. Additionally, a process is proposed for clot development from the existing fatty acid vesicles. |
| Databáze: | OpenAIRE |
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