Increase in Circulating Tumor Cells in Invasive Bladder Cancer After Transurethral Resection of Bladder Tumor
| Autor: | Kazuna Tsubouchi, Nobuhiro Haga, Tomoyuki Koguchi, Yoshiyuki Kojima, Seiji Hoshi, Hiroko Maruta, Hidenori Akaihata, Junya Hata, Soichiro Ogawa |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Urology Resection Circulating tumor cell Urethra Statistical significance Bladder tumor medicine Carcinoma Humans Neoplasm Invasiveness Bladder cancer business.industry General Medicine Middle Aged Neoplastic Cells Circulating medicine.disease Urinary Bladder Neoplasms Oncology Cohort Urologic Surgical Procedures Female Prospective research business |
| Zdroj: | Anticancer Research. 40:4299-4307 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14432 |
| Popis: | Background/aim The present research was performed to clarify the differences in circulating tumor cells (CTCs) counts between non-muscle-invasive (NMIBC) and muscle-invasive (MIBC) bladder cancer following transurethral resection of bladder tumor (TURBT). Patients and methods The cohort in the prospective research was categorized into the NMIBC (n=13) and the MIBC (n=13) groups. The pre- and postoperative number of CTCs was counted by the FISHMAN-R® system. Results The difference of the number of preoperative CTCs between the NMIBC group (2.3±2.6) and MIBC group (4.8±4.2) did not reach statistical significance (p=0.08). However, there was a significantly greater increase in postoperative CTC count in the MIBC group (14.6±14.6) than in the NMIBC group (3.1±2.1, p=0.01). Conclusion After TURBT, more carcinoma cells can be discharged from the bladder in the MIBC. Excessive deep layer resection and excessive pressure of the infusion fluid during TURBT should be avoided in patients with MIBC. |
| Databáze: | OpenAIRE |
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