Tailoring of arteriovenous graft-to-vein anastomosis angle to attenuate pathological flow fields
Autor: | Mohamed A. Zayed, Dillon Williams, Eric C. Leuthardt, Guy M. Genin |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Science 030232 urology & nephrology 030204 cardiovascular system & hematology Anastomosis Article End stage renal disease 03 medical and health sciences 0302 clinical medicine Arteriovenous Shunt Surgical Renal Dialysis Internal medicine medicine Shear stress Humans Computer Simulation Vein Multidisciplinary business.industry Renal replacement therapy Arteriovenous Anastomosis Hemodynamics Models Cardiovascular medicine.disease Thrombosis Computational biology and bioinformatics Shear rate Stenosis medicine.anatomical_structure surgical procedures operative Arteriovenous Fistula Cardiology Medicine Kidney Failure Chronic Hemodialysis Stress Mechanical business Blood Flow Velocity |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
ISSN: | 2045-2322 |
Popis: | Arteriovenous grafts are routinely placed to facilitate hemodialysis in patients with end stage renal disease. These grafts are conduits between higher pressure arteries and lower pressure veins. The connection on the vein end of the graft, known as the graft-to-vein anastomosis, fails frequently and chronically due to high rates of stenosis and thrombosis. These failures are widely believed to be associated with pathologically high and low flow shear strain rates at the graft-to-vein anastomosis. We hypothesized that consistent with pipe flow dynamics and prior work exploring vein-to-artery anastomosis angles in arteriovenous fistulas, altering the graft-to-vein anastomosis angle can reduce the incidence of pathological shear rate fields. We tested this via computational fluid dynamic simulations of idealized arteriovenous grafts, using the Bird-Carreau constitutive law for blood. We observed that low graft-to-vein anastomosis angles ($$ < 20 ∘ ) led to increased incidence of pathologically low shear rates, and that high graft-to-vein anastomosis angles ($$>40^{\circ }$$ > 40 ∘ ) led to increased incidence of pathologically high shear rates. Optimizations predicted that an intermediate ($$\sim 30^\circ$$ ∼ 30 ∘ ) graft-to-anastomosis angle was optimal. Our study demonstrates that graft-to-vein anastomosis angles can significantly impact pathological flow fields, and can be optimized to substantially improve arteriovenous graft patency rates. |
Databáze: | OpenAIRE |
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