RASSF7 and RASSF8 proteins are predictive factors for development and metastasis in malignant thyroid neoplasms
| Autor: | Shijie Xin, Ying-hou Wang, Zhi-quan Duan, Jian Zhang, Xi Li, Ge Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
endocrine system Pathology medicine.medical_specialty Goiter genetic structures Medullary cavity endocrine system diseases Thyroid Gland lcsh:RC254-282 Metastasis Thyroid carcinoma Tumor stage Humans Medicine Radiology Nuclear Medicine and imaging Thyroid Neoplasms Domain family business.industry Tumor Suppressor Proteins Carcinoma Thyroid General Medicine Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunohistochemistry thyroid carcinoma Carcinoma Papillary eye diseases Carcinoma Neuroendocrine medicine.anatomical_structure Oncology Thyroid Cancer Papillary RASSF8 RASSF7 Female business Goiter Nodular Transcription Factors |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 9, Iss 7, Pp 173-177 (2013) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Objectives: To study the expression status of Ras-association domain family 7 (RASSF7) and Ras-association domain family 8 (RASSF8) in nodular thyroid goiter (NTG), medullary thyroid carcinoma (MTC), and papillary thyroid carcinoma (PTC) and establish whether a correlation exists between the presence of RASSF7 and RASSF8 proteins and clinicopathological parameters of the disease. Materials and Methods: RASSF7 and RASSF8 protein expression was examined immunohistochemically on paraffin-embedded thyroid tissues from 112 cases with PTC, 20 cases with MTC, and 38 cases with NTG. Results: The immunohistochemical expression of RASSF7 and RASSF8 was higher in PTC and MTC than in NTG (P < 0.001). In thyroid carcinomas, RASSF7 and RASSF8 expression was significantly correlated with a more advanced TNM stage (P = 0.035, P = 0.037), age, sex, lymph node metastasis (P = 0.006, P = 0.002), and tumor size (P = 0.012, P = 0.015). Conclusions: RASSF7 and RASSF8 expression was increased in PTC and MTC compared to NTG, and this may be linked to the development and progression of thyroid carcinoma. In addition, these proteins were correlated with more advanced tumor stages, tumor size, and metastasis. |
| Databáze: | OpenAIRE |
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