Signet ring cell carcinoma of the gastrointestinal tract: National trends on treatment effects and prognostic outcomes
| Autor: | Jan Franko, Jessica D. Sedinkin, Mayin Lin, Viet H. Le, May C. Tee, Shankar Raman, Daniela Frankova |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Colon carcinoma Malignancy Gastroenterology Small bowel carcinoma Rectal carcinoma Cohort Studies Stomach Neoplasms Signet ring cell carcinoma Internal medicine medicine Clinical endpoint Humans RC254-282 Aged Gastrointestinal tract business.industry Proportional hazards model Esophagus carcinoma Hazard ratio Gastric carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer Middle Aged Prognosis medicine.disease Survival Analysis Gastrointestinal Tract Oncology Adenocarcinoma Female business Carcinoma Signet Ring Cell |
| Zdroj: | Cancer Treatment and Research Communications, Vol 29, Iss, Pp 100475-(2021) |
| ISSN: | 2468-2942 |
| DOI: | 10.1016/j.ctarc.2021.100475 |
| Popis: | Background: Signet ring cell carcinoma (SRCC) is a distinct malignancy occurring across the tubular gastrointestinal tract (tGIT). We comprehensively examined the outcomes of patients diagnosed with SRCC across tGIT. Methods: SRCC and not-otherwise-specified adenocarcinoma (NOS) patients reported to the National Cancer Database from 2004 to 2015 were included. Baseline characteristics, outcomes and site-specific adjusted hazard ratios (aHR) derived from Cox models of SRCC patients were compared to those of NOS patients. Overall survival (OS) was primary endpoint. Results: A total of 41,686 SRCC (4.6%) and 871,373 NOS patients (95.4%) were included. SRCC patients were younger (63.1 ± 14.7 vs. 67.0 ± 13.4 y, p |
| Databáze: | OpenAIRE |
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