B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights
| Autor: | Klaus Dornmair, Edgar Meinl, R. Hohlfeld |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Multiple Sclerosis
Proteome T-Lymphocytes T cell medicine.disease_cause Autoimmunity Antigen medicine Animals Humans Nerve Growth Factors B-Lymphocytes business.industry Multiple sclerosis T-cell receptor Experimental autoimmune encephalomyelitis Autoantibody Brain medicine.disease medicine.anatomical_structure Neurology Immunology Neurology (clinical) business Cell Adhesion Molecules Neuroscience |
| Zdroj: | Journal of the Neurological Sciences. 274:5-8 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2008.07.006 |
| Popis: | In experimental autoimmune encephalomyelitis (EAE), several target antigens of encephalitogenic T- and B-cell responses have been identified. However, in human multiple sclerosis (MS) the target antigens of pathogenic T and B cells have remained conjectural. Here we discuss how recent methodological advances have offered new insights into the nature of B- and T-cell receptor repertoires expressed in MS tissues, and how novel approaches have helped to identify neurofascin as a target of anti-axonal autoantibodies in MS and EAE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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