Chelatable iron and copper can be released from extracorporeally circulated blood during cardiopulmonary bypass
| Autor: | John M.C. Gutteridge, Timothy E. Evans, Gregory J. Quinlan, Neil E. Moat |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Male
Neutrophils Bleomycin-detectable iron medicine.medical_treatment Biophysics chemistry.chemical_element Iron Chelating Agents Biochemistry Antioxidants law.invention chemistry.chemical_compound Bleomycin Extracorporeal Membrane Oxygenation Phenanthroline-detectable copper Structural Biology law Superoxides Elastase Genetics Cardiopulmonary bypass Extracorporeal membrane oxygenation medicine Humans Molecular Biology Pancreatic elastase Bypass surgery Cardiopulmonary Bypass Pancreatic Elastase Superoxide Proteolytic enzymes Ceruloplasmin Cell Biology Hydrogen Peroxide Oxygen radical Copper chemistry Caeruloplasmin Circulatory system Reoxygenation injury Haemoglobin Oxidation-Reduction Phenanthrolines |
| Zdroj: | FEBS Letters. (1-2):103-106 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(93)80974-Y |
| Popis: | During cardiopulmonary bypass surgery blood is extracorporeally oxygenated and circulated before returning to the systemic arterial circulation. Blood undergoing extracorporeal dilution and circulation is exposed to non-physiological surfaces, which cause the activation of several regulatory cascades. Cells are also subjected to damaging shear stresses. Under such conditions neutrophils can be ‘activated’ to release reactive oxygen intermediates such as O2− and H2O2, and other cells can release proteolytic enzymes and metalloproteins. Collectively, these events can result in the release of micromolar quantities of redox active iron and copper. Bleomycin-detectable iron and phenanthroline-detectable copper were found in two out of four mock bypass experiments. However, there was no correlation between the presence of chelatable iron and copper and the activation of neutrophils measured as elastase. |
| Databáze: | OpenAIRE |
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