Timing of adjuvant chemotherapy after limb amputation and effect on outcome in dogs with appendicular osteosarcoma without distant metastases
| Autor: | Katherine Smallwood, Gerry Polton, Lida Bicanova, Laura Marconato, Silvia Sabattini, Ombretta Capitani, Franck Floch, Riccardo Finotello, Damiano Stefanello, Emanuela Maria Morello, Maria Teresa Camerino, Ondrej Skor, Paolo Buracco |
|---|---|
| Přispěvatelé: | Marconato L., Buracco P., Polton G.A., Finotello R., Stefanello D., Skor O., Bicanova L., Capitani O., Floch F., Morello E., Camerino M.T., Smallwood K., Sabattini S. |
| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Adjuvant chemotherapy medicine.medical_treatment timing of chemotherapy Bone Neoplasms Bone Neoplasm chemotherapy Amputation Surgical Dogs Retrospective Studie Dog Medicine Animals Dog Diseases Amputation appendicular neoplasms Retrospective Studies appendicular osteosarcoma dog amputation chemotherapy timing of chemotherapy Chemotherapy Osteosarcoma General Veterinary Animal business.industry Retrospective cohort study Limb amputation musculoskeletal system medicine.disease Time optimal Surgery Chemotherapy Adjuvant embryonic structures Dog Disease business |
| Zdroj: | Journal of the American Veterinary Medical Association. 259(7) |
| ISSN: | 1943-569X |
| Popis: | OBJECTIVE To determine an optimal time interval between amputation and initiation of adjuvant chemotherapy (TIamp-chemo) in dogs with appendicular osteosarcoma without distant metastases and whether TIamp-chemo was associated with outcome. ANIMALS 168 client-owned dogs treated at 9 veterinary oncology centers. PROCEDURES Data were collected from the dogs’ medical records concerning potential prognostic variables and outcomes. Dogs were grouped as to whether they received chemotherapy within 3, 5, 7, 10, 15, 20, 30, or > 30 days after amputation of the affected limb. Analyses were performed to identify variables associated with time to tumor progression and survival time after limb amputation and to determine an optimal TIamp-chemo. RESULTS Median TIamp-chemo was 14 days (range, 1 to 210 days). Median time to tumor progression for dogs with a TIamp-chemo ≤ 5 days (375 days; 95% CI, 162 to 588 days) was significantly longer than that for dogs with a TIamp-chemo > 5 days (202 days; 95% CI, 146 to 257 days). Median overall survival time for dogs with a TIamp-chemo ≤ 5 days (445 days; 95% CI, 345 to 545 days) was significantly longer than that for dogs with a TIamp-chemo > 5 days (239 days; 95% CI, 186 to 291 days). CONCLUSIONS AND CLINICAL RELEVANCE Findings indicated that early (within 5 days) initiation of adjuvant chemotherapy after limb amputation was associated with a significant and clinically relevant survival benefit for dogs with appendicular osteosarcoma without distant metastases. These results suggested that the timing of chemotherapy may be an important prognostic variable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|