From Ras to Rap and Back, a Journey of 35 Years
Autor: | Johannes L. Bos |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Mutation Oncogene Retrospective Oncogenes Biology medicine.disease_cause Actin cytoskeleton General Biochemistry Genetics and Molecular Biology Cell biology Closest relatives 03 medical and health sciences Signaling network 030104 developmental biology rap GTP-Binding Proteins medicine Cell Adhesion ras Proteins Animals Humans Signal transduction Cell adhesion Early analysis Signal Transduction |
Zdroj: | Cold Spring Harbor perspectives in medicine. 8(2) |
ISSN: | 2157-1422 |
Popis: | Our laboratory has studied Ras and Ras-like proteins since the discovery of the Ras oncogene 35 years ago. In this review, I will give an account of what we have done in these 35 years and indicate the main papers that have guided our research. Our efforts started with the early analysis of mutant Ras in human tumors followed by deciphering of the role of Ras in signal transduction pathways. In an attempt to interfere in Ras signaling we turned to Rap proteins. These proteins are the closest relatives of Ras and were initially identified as Ras antagonists. However, our studies revealed that the Rap signaling network primarily is involved in spatiotemporal control of cell adhesion, in part through regulation of the actin cytoskeleton. More recently we returned to Ras, trying to interfere in Ras signaling by combinatorial drug testing using the organoid technology. |
Databáze: | OpenAIRE |
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