Mapping typical and hypokinetic dysarthric speech production network using a connected speech paradigm in functional MRI
| Autor: | Katherine Schiller, Megan Battles Parsons, Michael P. Cannito, Asim F. Choudhri, Wei Zhang, Mark S. LeDoux, Crystal G. Franklin, Peter T. Fox, Shalini Narayana |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
FSL FMRIB Software Library Speech production TE Echo Time MIPS Multiple Image Processing Station PET Positron Emission Tomography Audiology Apraxia Spasmodic dysphonia lcsh:RC346-429 Dysarthria 0302 clinical medicine Speech production network Motor speech Motor speech disorders BOLD Blood Oxygenation Level Dependent ASL Arterial Spinal Labeling Connected speech Brain Mapping GUI Graphical User Interface fMRI 05 social sciences Brain Regular Article PD Parkinson Disease Magnetic Resonance Imaging TR Repetition Time Neurology SPI{z}) Statistical Parametric Image of z score Hypokinetic dysarthria lcsh:R858-859.7 Female FLAME FMRIB's Local Analysis of Mixed Effects medicine.symptom Comprehension Psychology HKD hypokinetic Dysarthria psychological phenomena and processes SMA Supplemental Motor Area Adult medicine.medical_specialty Stuttering MNI Montreal Neurological Institute Cognitive Neuroscience SPN Speech Production Network M1 Primary Motor Cortex lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities Speech Disorders 050105 experimental psychology Young Adult 03 medical and health sciences rCBF regional Cerebral Blood Flow MEG Magnetoencephalography otorhinolaryngologic diseases medicine Humans Speech PMd dorsal PreMotor cortex 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging DICOM Digital Imaging and Communications in Medicine MCFLIRT Motion Correction and Linear Image Registration Tool lcsh:Neurology. Diseases of the nervous system Voice Disorders fMRI functional Magnetic Resonance Imaging Normal speech medicine.disease FWHM Full Width at Half Maximum BA Brodmann Area PET FEAT FMRI Expert Analysis Tool DIVA Directions into Velocities of Articulators Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 27, Iss, Pp 102285-(2020) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2020.102285 |
| Popis: | Highlights • Developed and validated an overt continuous speech paradigm for use in fMRI. • The speech paradigm successfully identified the neural circuit of speech production. • The speech paradigm is effective in mapping disordered motor speech. • The fMRI paradigm will be useful for studying normal and disordered speech. We developed a task paradigm whereby subjects spoke aloud while minimizing head motion during functional MRI (fMRI) in order to better understand the neural circuitry involved in motor speech disorders due to dysfunction of the central nervous system. To validate our overt continuous speech paradigm, we mapped the speech production network (SPN) in typical speakers (n = 19, 10 females) and speakers with hypokinetic dysarthria as a manifestation of Parkinson disease (HKD; n = 21, 8 females) in fMRI. We then compared it with the SPN derived during overt speech production by 15O-water PET in the same group of typical speakers and another HKD cohort (n = 10, 2 females). The fMRI overt connected speech paradigm did not result in excessive motion artifacts and successfully identified the same brain areas demonstrated in the PET studies in the two cohorts. The SPN derived in fMRI demonstrated significant spatial overlap with the corresponding PET derived maps (typical speakers: r = 0.52; speakers with HKD: r = 0.43) and identified the components of the neural circuit of speech production belonging to the feedforward and feedback subsystems. The fMRI study in speakers with HKD identified significantly decreased activity in critical feedforward (bilateral dorsal premotor and motor cortices) and feedback (auditory and somatosensory areas) subsystems replicating previous PET study findings in this cohort. These results demonstrate that the overt connected speech paradigm is feasible during fMRI and can accurately localize the neural substrates of typical and disordered speech production. Our fMRI paradigm should prove useful for study of motor speech and voice disorders, including stuttering, apraxia of speech, dysarthria, and spasmodic dysphonia. |
| Databáze: | OpenAIRE |
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