Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function
| Autor: | William G. Anderson, Paul W. Erhardt, Richard J. Gorczynski, Chi M. Woo |
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| Rok vydání: | 1982 |
| Předmět: |
Time Factors
Adrenergic receptor Chemical Phenomena Stereochemistry Hydrochloride Adrenergic beta-Antagonists Guinea Pigs Blood Pressure In Vitro Techniques Muscle Smooth Vascular Propanolamines chemistry.chemical_compound Structure-Activity Relationship Dogs In vivo Drug Discovery Animals Receptor chemistry.chemical_classification Aryl Muscle Smooth Chemistry chemistry Propionate Molecular Medicine Propanolamine |
| Zdroj: | Journal of medicinal chemistry. 25(12) |
| ISSN: | 0022-2623 |
| Popis: | Several short-acting beta-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems. In particular, methyl 3-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models. |
| Databáze: | OpenAIRE |
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