Genetic polymorphism in intron 6 of the LMP7 gene in Japanese and its association with sarcoidosis
| Autor: | Seiko Ohno, Mami Ishihara, Taeko Naruse, Takako Ishida, Hidetoshi Inoko |
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| Rok vydání: | 1997 |
| Předmět: |
Proteasome Endopeptidase Complex
Sarcoidosis Immunology Polymerase Chain Reaction Biochemistry Linkage Disequilibrium Asian People Japan Multienzyme Complexes Polymorphism (computer science) Genetics medicine Humans Immunology and Allergy Allele Gene Alleles Polymerase Polymorphism Genetic biology Intron Proteins HLA-DR Antigens General Medicine Japanese population medicine.disease Introns Cysteine Endopeptidases biology.protein Polymorphism Restriction Fragment Length HLA-DRB1 Chains |
| Zdroj: | Tissue Antigens. 50:650-653 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | Genetic polymorphism in intron 6 of the LMP7 gene was investigated using polymerase chain reaction-restriction fragment length polymorphism in 90 unrelated healthy Japanese controls and 66 Japanese patients with sarcoidosis. Four alleles, including two new ones recently identified in Koreans, LMP7*C and LMP7*D, were found in the Japanese population. The frequency of LMP7*C in the sarcoidosis patients was higher than in the healthy controls. However, this difference might be explained by a secondary association with HLA-DRB1*08 in the HLA-DRB1 gene, which is thought to be the gene primarily responsible for susceptibility to sarcoidosis. |
| Databáze: | OpenAIRE |
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