Galantamine improves functional recovery and reduces lesion size in a rat model of spinal cord injury
| Autor: | Cristian Euzebio Teixeira, Laura E. Sperling, Marcelo Garrido dos Santos, Carlos Alexandre Netto, Eduardo Luis Konrath, Fabrício do Couto Nicola, Gabriele Gulielmin Didó, Karina Pires Reis, Patricia Pranke |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.drug_class Contusions Hindlimb Pharmacology Motor Activity Neuroprotection Lesion 03 medical and health sciences 0302 clinical medicine Galantamine Medicine Animals Rats Wistar Molecular Biology Spinal cord injury Spinal Cord Injuries business.industry CD68 General Neuroscience Neurogenesis Recovery of Function medicine.disease Rats 030104 developmental biology Neuroprotective Agents Acetylcholinesterase inhibitor Spinal Cord Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Locomotion Developmental Biology medicine.drug |
| Zdroj: | Brain research. 1724 |
| ISSN: | 1872-6240 |
| Popis: | Spinal cord injury (SCI) is a medical condition that currently lacks effective treatment. Galantamine is a reversible, competitive acetylcholinesterase inhibitor, used to treat patients with Alzheimeŕs disease. It has been demonstrated that galantamine increases cerebral neurogenesis and has a neuroprotective effect by binding to nicotinic receptors and has an anti-inflammatory effect due to its allosteric binding to the α7nAChR. In the present study, the effects of galantamine on functional recovery and histological outcome in a rat contusion model of SCI were analyzed. Male Wistar rats were submitted to SCI using a NYU/MASCIS impactor. The animals from the galantamine group were treated with 5 mg/kg galantamine intraperitoneally for 5 days. The Basso, Beattie and Bresnahan scale (BBB) was used to evaluate locomotor activity. The expression of beta3-tubulin, NFM, GFAP, O4, CD68 and CD3 was analyzed by flow cytometry. Rats that received galantamine had significantly higher BBB scores in comparison with the control lesion group. Galantamine treatment increased the percentage of NFM positive cells at 6 weeks post-injury and reduced the size of the lesion. The results indicate that galantamine increased tissue survival and accelerated hind limb motor function recovery. This is the first study that has shown the possibility of therapeutic use of galantamine in a model of acute spinal cord injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect