Genetic diversity in the modern horse illustrated from genome-wide SNP data
| Autor: | Hannes Lohi, Molly E. McCue, Tosso Leeb, Emmeline W. Hill, Jessica L. Petersen, Knut Røed, Telhisa Hasegawa, Maurizio Silvestrelli, Bianca Haase, Pieter A.J. Brama, M. Cecilia T. Penedo, Mark Vaudin, Claire M. Wade, Teruaki Tozaki, Ottmar Distl, Karin Hemmann, Michela Felicetti, Gabriella Lindgren, Richard J. Piercy, K. T. Graves, Laura Y Fox-Clipsham, June E Swinburne, Artur da Câmara Machado, Stefan Rieder, M. S. Lopes, James R. Mickelson, Danika L. Bannasch, Gérard Guérin, Marja Raekallio, Lisa S. Andersson, Matthew M. Binns, Beatrice A. McGivney, Nick Orr, Alexandre Secorun Borges, E. Gus Cothran, Jeanette Axelsson, Sofia Mikko, E. Bailey |
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| Přispěvatelé: | Coll Vet Med, University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, Coll Vet Med & Biomed Sci, Texas A&M University System, Department of Animal Bredding and Genetics, Swedish University of Agricultural Sciences (SLU), Dept Vet Sci, University of Kentucky, Sch Vet Med, University of California [Davis] (UC Davis), University of California-University of California, Equine Analysis, Dept Vet Clin Sci, Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), University College Dublin [Dublin] (UCD), Inst Biotechnol & Bioengn, Biotechnol Ctr Azores, Univ Azores, Inst Anim Breeding & Genet, University of Veterinary Medecine Hannover, Fac Vet Med, Università degli Studi di Perugia (UNIPG), Newmarket, Anim Hlth Trust, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, The University of Sydney, Nihon Bioresource College, Coll Agr Food Sci & Vet Med, Inst Genet, University of Bern, Breakthrough Breast Canc Res Ctr, Institute of Cancer Research (ICR), Comparat Neuromuscular Dis Lab, Royal Veterinary College, Agroscope Liebefeld Posieux Res Stn, Swiss Natl Stud Farm, Dept Basic Sci & Aquat Med, Norwegian School of Veterinary Science, Anim DNA Diagnost Ltd, Dept Mol Genet, Laboratory of Racing Chemistry, National Research Initiative from the United States Department of Agriculture-National Institute of Food and Agriculture (USDA-NIFA) [2008-35205-18766, 2009-55205-05254, 2012-67015-19432], Foundation for the Advancement of the Tennessee Walking Show Horse, Tennessee Walking Horse Foundation, National Institutes of Health-National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIHNAIMS) [1K08AR055713-01A2, 2T32AR007612], American Quarter Horse Foundation, Morris Animal Foundation [D07EQ-500], Swedish Research Council FORMAS [221-2009-1631, 2008-617], Swedish-Norwegian Foundation for Equine Research [H0847211, H0947256], Carl Tryggers Stiftelse [CTS 08: 29], FCT, DRCT, Science Foundation Ireland [04/Y11/B539], Volkswagen Stiftung und Niedersa chsisches Ministerium fur Wissenschaft und Kultur, Germany [VWZN2012], [FRCT/2011/317/005], College of Veterinary Medicine, College of Veterinary Medicine and Biomedical Science, Swedish University of Agricultural Sciences, School of Veterinary Medicine, Universidade Estadual Paulista (Unesp), Biotechnology Centre of Azores, Institute for Animal Breeding and Genetics, Faculty of Veterinary Medicine, Animal Health Trust, French National Institute for Agricultural Research-Animal Genetics and Integrative Biology Unit, Veterinary Science, College of Agriculture, Food Science and Veterinary Medicine, Institute of Genetics, Breakthrough Breast Cancer Research Centre, Comparative Neuromuscular Diseases Laboratory, Agroscope Liebefeld-Posieux Research Station, Animal DNA Diagnostics Ltd, University of Minnesota [Twin Cities], Dept Anim Breeding & Genet, Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Departments of Faculty of Veterinary Medicine, Veterinary Biosciences, Equine and Small Animal Medicine, Research Centre for Animal Welfare, Teachers' Academy |
| Rok vydání: | 2012 |
| Předmět: |
Evolutionary Genetics
LINKAGE DISEQUILIBRIUM Heredity genetic association MITOCHONDRIAL-DNA genotype [SDV]Life Sciences [q-bio] MULTILOCUS GENOTYPE DATA lcsh:Medicine Population genetics geographic origin Breeding 413 Veterinary science neighbor joining method BREEDS single nucleotide polymorphism genetic variability Natural Selection Cluster Analysis Animal Breeding lcsh:Science comparative study Animal Management 2. Zero hunger 0303 health sciences education.field_of_study Principal Component Analysis Multidisciplinary 630 Agriculture Population size MICROSATELLITE DIVERSITY 1184 Genetics developmental biology physiology Agriculture phenotypic variation 04 agricultural and veterinary sciences Genomics THOROUGHBRED HORSE gene isolation Breed horse 3. Good health Phenotypes 590 Animals (Zoology) ALLELE FREQUENCIES descriptive research Research Article population size Gene Flow population differentiation breed Animal Types education outcrossing Population Genotypes inbreeding Outcrossing Biology Large Animals Polymorphism Single Nucleotide animal tissue parsimony analysis 03 medical and health sciences MULTIPLE DOMESTICATION EVENTS Effective Population Size Genetics Animals controlled study POPULATION-STRUCTURE Horses Domestication gene location 030304 developmental biology Genetic diversity Evolutionary Biology nonhuman Population Biology lcsh:R Genetic Drift LINEAGES 0402 animal and dairy science 040201 dairy & animal science animal genetics Population bottleneck genetic selection Evolutionary biology Genetic Polymorphism lcsh:Q Veterinary Science human activities Animal Genetics Population Genetics |
| Zdroj: | PLoS ONE Petersen, Jessica L; Mickelson, James R; Cothran, E Gus; Andersson, Lisa S; Axelsson, Jeanette; Bailey, Ernie; Bannasch, Danika; Binns, Matthew M; Borges, Alexandre S; Brama, Pieter; da Câmara Machado, Artur; Distl, Ottmar; Felicetti, Michela; Fox-Clipsham, Laura; Graves, Kathryn T; Guérin, Gérard; Haase, Bianca; Hasegawa, Telhisa; Hemmann, Karin; Hill, Emmeline W; ... (2013). Genetic diversity in the modern horse illustrated from genome-wide SNP data. PLoS ONE, 8(1), e54997. Public Library of Science 10.1371/journal.pone.0054997 PLoS ONE, Public Library of Science, 2013, 8 (1), ⟨10.1371/journal.pone.0054997⟩ PLoS ONE, Vol 8, Iss 1, p e54997 (2013) PLoS One Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Plos One 1 (8), . (2013) |
| ISSN: | 1932-6203 |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:28:16Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:16Z : No. of bitstreams: 1 2-s2.0-84873867256.pdf: 796974 bytes, checksum: 64f172274307a2abd3e5977743eb1671 (MD5) Made available in DSpace on 2014-05-27T11:28:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-30 Horses were domesticated from the Eurasian steppes 5,000-6,000 years ago. Since then, the use of horses for transportation, warfare, and agriculture, as well as selection for desired traits and fitness, has resulted in diverse populations distributed across the world, many of which have become or are in the process of becoming formally organized into closed, breeding populations (breeds). This report describes the use of a genome-wide set of autosomal SNPs and 814 horses from 36 breeds to provide the first detailed description of equine breed diversity. FST calculations, parsimony, and distance analysis demonstrated relationships among the breeds that largely reflect geographic origins and known breed histories. Low levels of population divergence were observed between breeds that are relatively early on in the process of breed development, and between those with high levels of within-breed diversity, whether due to large population size, ongoing outcrossing, or large within-breed phenotypic diversity. Populations with low within-breed diversity included those which have experienced population bottlenecks, have been under intense selective pressure, or are closed populations with long breed histories. These results provide new insights into the relationships among and the diversity within breeds of horses. In addition these results will facilitate future genome-wide association studies and investigations into genomic targets of selection. © 2013 Petersen et al. University of Minnesota College of Veterinary Medicine, St Paul, MN Texas AandM University College of Veterinary Medicine and Biomedical Science, College Station, TX Swedish University of Agricultural Sciences Department of Animal Breeding and Genetics, Uppsala University of Kentucky Department of Veterinary Science, Lexington, KY University of California Davis School of Veterinary Medicine, Davis, CA Equine Analysis, Midway, KY University Estadual Paulista Department of Veterinary Clinical Science, Botucatu-SP University College Dublin School of Veterinary Medicine, Dublin University of Azores Institute for Biotechnology and Bioengineering Biotechnology Centre of Azores, Angra do Heroísmo University of Veterinary Medicine Hannover Institute for Animal Breeding and Genetics, Hannover University of Perugia Faculty of Veterinary Medicine, Perugia Animal Health Trust, Lanwades Park, Newmarket, Suffolk French National Institute for Agricultural Research-Animal Genetics and Integrative Biology Unit, Jouy en Josas University of Sydney Veterinary Science, New South Wales Nihon Bioresource College, Koga, Ibaraki University of Helsinki Faculty of Veterinary Medicine, Helsinki University College Dublin College of Agriculture, Food Science and Veterinary Medicine, Belfield, Dublin University of Bern Institute of Genetics, Bern Institute of Cancer Research Breakthrough Breast Cancer Research Centre, London Royal Veterinary College Comparative Neuromuscular Diseases Laboratory, London Swiss National Stud Farm Agroscope Liebefeld-Posieux Research Station, Avenches Norwegian School of Veterinary Science Department of Basic Sciences and Aquatic Medicine, Oslo Animal DNA Diagnostics Ltd, Cambridge Laboratory of Racing Chemistry Department of Molecular Genetics, Utsunomiya, Tochigi |
| Databáze: | OpenAIRE |
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