HLA-linked susceptibility gene of Takayasu disease
| Autor: | Keishu Yasuda, Katsuaki Itakura, Tatsuzo Tanabe, Junko Moriuchi, Akemi Wakisaka, Miki Aizawa, Akira Yokota |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Genetic Linkage
Immunology Radioimmunoassay Susceptibility gene Human leukocyte antigen Aortitis syndrome Autoimmune Diseases Japan Antigen HLA Antigens Humans Immunology and Allergy Medicine In patient Takayasu Disease Gene HLA-D Antigens Aortic Arch Syndromes business.industry Histocompatibility Antigens Class II General Medicine Takayasu Arteritis Female Disease Susceptibility business |
| Zdroj: | Human Immunology. 4:87-91 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/0198-8859(82)90054-4 |
| Popis: | The HLA-A, B, DR and MB antigens were investigated in patients suffering from Takayasu disease (Aortitis syndrome). Out of twenty-one HLA-A and B antigens tested, only HLA-Bw92 was significantly deviated (30/47, PF = 63.8%, RR = 7.8) from the controls (14/76, PF = 18.4%). Since in the Japanese, HLA-Bw52 is in positive linkase disequilibria with HLA-DR2 and MB1, the association of the DR2 and MB1 antigens with Takayasu disease was studied. The HLA-DR2 antigen was significantly increased (23/30, PF = 76.7%, RR = 6.0) in patients compared with the controls (18/51, PF = 35.3%). Moreover, an almost perfect association of MB1 (29/30, PF = 96.7%, RR = 12.6) with Takayasu disease was demonstrated. This finding supports the hypothesis that the genes in the HLA-D region play a major role in determining the susceptibility to Takayasu disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|