Improved cerebral microbleeds detection using their magnetic signature on T2*-phase-contrast: a comparison study in a clinical setting

Autor: Ali Bouyahia, Anne Bertrand, Bruno Law-Ye, Nathalie Thiery, Didier Dormont, Nadya Pyatigorskaya, Carole Dufouil, Christine Delmaire, Fatma Ouamer, Marie Chupin, Takoua Kaaouana, Ludovic de Rochefort
Přispěvatelé: Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Acquisition et de Traitement des Images [Paris], Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de recherches éducation et formation (CREF), Université Paris Nanterre (UPN), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Services de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Imagerie par Résonance Magnétique Médicale et Multi-Modalités (IR4M), Université Paris-Sud - Paris 11 (UP11)-Hôpital Bicêtre-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Inria de Paris, Service de Neuroradiologie [CHU Pitié-Salpêtrière], bertrand, anne, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Inria de Paris
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Cognitive Neuroscience
Phase contrast microscopy
[SDV]Life Sciences [q-bio]
Magnetic signature
lcsh:Computer applications to medicine. Medical informatics
Sensitivity and Specificity
lcsh:RC346-429
030218 nuclear medicine & medical imaging
law.invention
Magnetic susceptibility
03 medical and health sciences
0302 clinical medicine
law
Image Interpretation
Computer-Assisted
False positive paradox
Image Processing
Computer-Assisted
Humans
SWI
Radiology
Nuclear Medicine and imaging
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
lcsh:Neurology. Diseases of the nervous system
Cerebral Hemorrhage
Reproducibility
Minimum intensity projection
business.industry
Reproducibility of Results
Pattern recognition
Regular Article
Magnetic Resonance Imaging
3. Good health
Clinical Practice
[SDV] Life Sciences [q-bio]
Neurology
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Susceptibility weighted imaging
Comparison study
Microbleeds
lcsh:R858-859.7
Neurology (clinical)
Artificial intelligence
Psychology
business
030217 neurology & neurosurgery
Biomedical engineering
Phase MRI
Zdroj: Neuroimage-Clinical
Neuroimage-Clinical, 2016, ⟨10.1016/j.nicl.2016.08.005⟩
NeuroImage: Clinical, Vol 15, Iss, Pp 274-283 (2017)
Neuroimage-Clinical, Elsevier, 2016, ⟨10.1016/j.nicl.2016.08.005⟩
NeuroImage : Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2016.08.005⟩
Popis: Introduction/purpose In vivo detection of cerebral microbleeds (CMBs) from T2* gradient recalled echo (GRE) magnitude image suffers from low specificity, modest inter-rater reproducibility and is biased by its sensitivity to acquisition parameters. New methods were proposed for improving this identification, but they mostly rely on 3D acquisitions, not always feasible in clinical practice. A fast 2D phase processing technique for computing internal field maps (IFM) has been shown to make it possible to characterize CMBs through their magnetic signature in routine clinical setting, based on 2D multi-slice acquisitions. However, its clinical interest for CMBs identification with respect to more common images remained to be assessed. To do so, systematic experiments were undertaken to compare the ratings obtained by trained observers with several image types, T2* magnitude, Susceptibility Weighted Imaging reconstructions (SWI) and IFM built from the same T2*-weighted acquisition. Materials/methods 15 participants from the MEMENTO multi-center cohort were selected: six subjects with numerous CMBs (20 ± 6 CMBs), five subjects with a few CMBs (2 ± 1 CMBs) and four subjects without CMB. 2D multi-slice T2* GRE sequences were acquired on Philips and Siemens 3T systems. After pilot experiments, T2* magnitude, Susceptibility Weighted Imaging (SWI) minimum intensity projection (mIP) on three slices and IFM were considered for the rating experiments. A graphical user interface (GUI) was designed in order to consistently display images in random order. Six raters of various background and expertise independently selected “definite” or “possible” CMBs. Rating results were compared with respect to a specific consensus reference, on both lesion and subject type points of view. Results IFM yielded increased sensitivity and decreased false positives rate (FPR) for CMBs identification compared to T2* magnitude and SWI-mIP images. Inter-rater variability was decreased with IFM when identifying subjects with numerous lesions, with only a limited increase in rating time. IFM thus appears as an interesting candidate to improve CMBs identification in clinical setting.
Highlights • We introduce an evaluation of phase-contrast for CMBs detection in clinical setting. • Comparison included T2* magnitude, SWI-mIP and IFM images using a specific GUI. • Rating results showed an improved sensitivity of IFM compared to T2*and SWI-mIP. • A decreased false positive rate with IFM with respect to T2*and SWI-mIP was proved. • We demonstrate a decreased inter-rater variability with IFM.
Databáze: OpenAIRE
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