Platelet inhibitors versus anticoagulants for prevention of aorto-coronary bypass graft occlusion
| Autor: | N. Goebel, W. Steinbrunn, Krayenbühl Hp, K. Speiser, Å. Senning, M. I. Turina, Rothlin M, N. Pfluger |
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| Přispěvatelé: | University of Zurich, Rothlin, M E |
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Ticlopidine 610 Medicine & health Coronary Disease Thiophenes Placebo Coronary Angiography 142-005 142-005 2705 Cardiology and Cardiovascular Medicine Postoperative Complications medicine Humans Coronary Artery Bypass Prothrombin time Acenocoumarol Clinical Trials as Topic medicine.diagnostic_test business.industry Graft Occlusion Vascular Anticoagulants Perioperative Middle Aged Surgery medicine.anatomical_structure Hemostasis Anesthesia Angiography 570 Life sciences biology Cardiology and Cardiovascular Medicine business medicine.drug Artery |
| Zdroj: | European heart journal. 6(2) |
| ISSN: | 0195-668X |
| Popis: | The effects of the antiaggregant substance ticlopidine and of the anticoagulant acenocoumarol on patency rates of aorto-coronary bypass grafts were compared in a prospective randomized trial. Ticlopidine, 250 mg b.i.d. was administered orally from the first postoperative day till angiography, while anticoagulation with acenocoumarol was initiated on the second to third postoperative day. Side-effects of ticlopidine were rare and patient management with the standard dosage of this drug was easier than oral anticoagulation. From an initial group of 166 randomized patients 149 completed the trial by coronary angiography three months postoperatively. The 78 patients in the ticlopidine group showed a compliance of 85%. The average prothrombin time in the 71 patients receiving acenocoumarol was 26.9%. Detailed statistical analysis of the two study groups revealed no reason to doubt the correctness of randomization. Coronary angiography showed an average patency rate per patient of 84% with ticlopidine and of 82% with acenocoumarol. This and various other measures of graft occlusion did not reveal any substantial difference in graft patency of patients receiving ticlopidine or acenocoumarol. It is concluded that ticlopidine may well be used instead of anticoagulants for prevention of postoperative occlusion of aorto-coronary bypass grafts. |
| Databáze: | OpenAIRE |
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