The Salmonella genomic island 1 is specifically mobilized in trans by the IncA/C multidrug resistance plasmid family
| Autor: | Axel Cloeckaert, Benoît Doublet, Gregory Douard, Karine Praud |
|---|---|
| Přispěvatelé: | Infectiologie Animale et Santé Publique (UR IASP), Institut National de la Recherche Agronomique (INRA) |
| Rok vydání: | 2010 |
| Předmět: |
Evolutionary Genetics
Salmonella lcsh:Medicine résistance aux antibiotiques medicine.disease_cause Polymerase Chain Reaction Integrons Plasmid Genomic island Drug Resistance Multiple Bacterial Enzyme Inhibitors lcsh:Science Genome Evolution Genetics bactérie 0303 health sciences Multidisciplinary biology Salmonella enterica DNA Restriction Enzymes Genomics gène de résistance Anti-Bacterial Agents Bacterial Pathogens Horizontal gene transfer plasmide ilot génomique beta-Lactamase Inhibitors Plasmids Research Article Evolutionary Processes Genomic Islands [SDV.BC]Life Sciences [q-bio]/Cellular Biology Microbiology beta-Lactamases 03 medical and health sciences Antibiotic resistance medicine Escherichia coli Biology Microbial Pathogens 030304 developmental biology Evolutionary Biology Models Genetic 030306 microbiology lcsh:R Computational Biology Sequence Analysis DNA biology.organism_classification Multiple drug resistance Genes Bacterial Microbial Evolution lcsh:Q |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2010, 5 (12), pp.e15302. ⟨10.1371/journal.pone.0015302⟩ Plos One 12 (5), e15302. (2010) PLoS ONE, Vol 5, Iss 12, p e15302 (2010) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0015302⟩ |
| Popis: | International audience; BACKGROUND: The Salmonella genomic island 1 (SGI1) is a Salmonella enterica-derived integrative mobilizable element (IME) containing various complex multiple resistance integrons identified in several S. enterica serovars and in Proteus mirabilis. Previous studies have shown that SGI1 transfers horizontally by in trans mobilization in the presence of the IncA/C conjugative helper plasmid pR55. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report the ability of different prevalent multidrug resistance (MDR) plasmids including extended-spectrum β-lactamase (ESBL) gene-carrying plasmids to mobilize the multidrug resistance genomic island SGI1. Through conjugation experiments, none of the 24 conjugative plasmids tested of the IncFI, FII, HI2, I1, L/M, N, P incompatibility groups were able to mobilize SGI1 at a detectable level (transfer frequency |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|