Synthesis and antitumor activities of sinomenine derivatives on rings A and C
| Autor: | Can-Jing Wei, Teng-Fei Ji, Jia-Wen Hu, Xue Wang, Fang Xu, Jia-Jia Wang, Meng-Jiao Shi, Bo Zhen, Jinhua Wang, Guanhua Du |
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| Rok vydání: | 2017 |
| Předmět: |
Stereochemistry
Cell Survival Pharmaceutical Science Antineoplastic Agents Glioma cell 010402 general chemistry 01 natural sciences Analytical Chemistry Structure-Activity Relationship Cell Line Tumor Drug Discovery Humans Nuclear Magnetic Resonance Biomolecular Sinomenine Triple-negative breast cancer Cell Proliferation Pharmacology Molecular Structure 010405 organic chemistry Human lung cancer Chemistry Organic Chemistry General Medicine 0104 chemical sciences Human colon cancer Complementary and alternative medicine Morphinans Cell culture Drug Design Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Journal of Asian natural products research. 20(3) |
| ISSN: | 1477-2213 |
| Popis: | A series of new sinomenine derivatives were designed, synthesized, and evaluated in tumor inhibitory activity, such as human triple negative breast cancer cell line (MDA-MB-231), glioma cell line (A172), human lung cancer cell line (A549), human colon cancer cell line (HCT-8). The modifications were carried out on rings A and C of the sinomenine by esterificating on phenolic hydroxyl with good yields. The highlight of this work was that the synthetic procedures were concise and sinomenine derivatives demonstrated promising antitumor activities. |
| Databáze: | OpenAIRE |
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