| Autor: |
A-Long Cui, Zi-Ying Zhou, Ya-Li Wang, Lin-Tao Wu, Si-Tu Xue, Zhuo-Rong Li |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Future medicinal chemistry. |
| ISSN: |
1756-8927 |
| Popis: |
Background: Given the benzimidazole derivatives have anti-ovarian cancer effects, the authors aimed to determine whether benzimidazole-2-substituted pyridine and phenyl propenone derivatives exert anti-ovarian cancer activity. Materials & methods: 21 derivatives were synthesized and assayed for their antiproliferative activities. Western blotting in A2780 cells was used to detect the effects of compound A-6 on apoptosis-related proteins. Invasion, migration and apoptosis were assayed in SKOV3 cells treated with A-6. The in vivo activity was also examined. Results: A-6 could inhibit proliferation, invasion and migration and induce apoptosis in SKOV3 cells. Additionally, A-6 had potent inhibitory activity in a xenograft mouse model. Conclusion: A-6 shows potent efficacy in the treatment of ovarian cancer and may be a potential antitumor agent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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