CD10-positive Stromal Cells in Gastric Carcinoma: Correlation with Invasion and Metastasis
| Autor: | Heng-Hui Ma, Wen-Bin Huang, Li-Hua Zhang, Zhen-feng Lu, Xiaojun Zhou, Kui Meng, Jie-Yu Chen |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Stromal cell Metastasis Stomach Neoplasms immune system diseases hemic and lymphatic diseases Internal medicine Lymph node stromal cell medicine Carcinoma Humans Neoplasm Invasiveness Radiology Nuclear Medicine and imaging neoplasms Aged Aged 80 and over business.industry Germinal center General Medicine Middle Aged medicine.disease Lymphatic Metastasis Cancer research Immunohistochemistry Female Neprilysin Lymph Nodes Stromal Cells Clone (B-cell biology) Breast carcinoma business |
| Zdroj: | Japanese Journal of Clinical Oncology. 35:245-250 |
| ISSN: | 1465-3621 0368-2811 |
| Popis: | Background: CD10 is a cell surface metalloproteinase expressed by a variety of normal cell types, including lymphoid precursor cells, germinal center B lymphocytes and some epithelial cells. Although accumulating data indicate that CD10 expression by stromal cells is involved in colorectal carcinogenesis and it is a novel prognostic factor in breast carcinoma, CD10-positive stromal cells and their correlation with invasion and metastasis have not been studied in gastric carcinoma. The aim of this study was to immunohistochemically investigate the rate of CD10 production in the stromal cells in our gastric carcinoma collection and clarify its correlation with invasion and metastasis. Methods: One hundred and sixteen cases of gastric carcinoma were analyzed immunohistochemically using a monoclonal CD10 antibody (clone 56C6). Results: The expression of CD10 by stromal cells was significantly higher in the primary gastric carcinomasthaninnormalanddysplasiamucosas(P =0.014).MorefrequentexpressionofCD10 by stromal cells was detected in differentiated carcinoma than in undifferentiated carcinoma (P < 0.001). CD10 expression by the stromal cells was associated with depth of invasion and lymph node metastasis (P < 0.05). Stromal CD10 expression was lower in gastric carcinoma without vessel invasion than in those with vessel invasion (P = 0.001). However, no association was observed between stromal CD10 expression and TNM stage. In differentiated carcinoma, stromal CD10 expression was associated with the depth of invasion, lymph node metastasis, vessel invasion and TNM stage (P < 0.01). Conclusion: These results indicate that stromal cells expressing CD10 may play an important role in gastric carcinogenesis. CD10 expression by stromal cells seems to promote invasion and metastasis of differentiated gastric carcinoma. |
| Databáze: | OpenAIRE |
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