Frequency of serological markers of rheumatoid arthritis in adult patients with active celiac disease
| Autor: | Mariam Ghozzi, Sarra Melayah, Najeh Adaily, Ibtissem Ghedira |
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| Rok vydání: | 2022 |
| Předmět: |
Microbiology (medical)
Adult Male Biochemistry (medical) Clinical Biochemistry Public Health Environmental and Occupational Health Enzyme-Linked Immunosorbent Assay Hematology Peptides Cyclic Arthritis Rheumatoid Medical Laboratory Technology Celiac Disease Rheumatoid Factor Immunology and Allergy Humans Female Research Articles Autoantibodies Retrospective Studies |
| Zdroj: | J Clin Lab Anal |
| ISSN: | 1098-2825 |
| Popis: | BACKGROUND: Celiac disease (CD) and rheumatoid arthritis (RA) are multisystem autoimmune diseases affecting 1% of general populationa. Both diseases share genetic and immunological features. AIM: In this retrospective study, we aim to determine the frequency of auto‐antibodies of RA in adult patients with CD. MATERIALS AND METHODS: Seventy seven adult patients with active CD were included in the present study. Ninety healthy blood donors (HBD) served as control group. Anti‐cyclic citrullinated peptides antibodies (CCP‐Ab) and rheumatoid factors (RF; IgA, IgG and IgM) were determined by enzyme linked immunosorbent assay (ELISA) for patients and control group. For statistical analysis, we used Chi‐square or Fisher's exact test. RESULTS: Our study included 77 adult patients with active celiac disease (57 female, 20 male). Twenty‐four (31.2%) active celiac patients and 7 (7.8%) blood donors had CCP‐Ab or RF (31.2% vs 7.8%, p |
| Databáze: | OpenAIRE |
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