Bone morphogenetic protein-2 and bone therapy: successes and pitfalls
| Autor: | Bonnie Poon, Tram Kha, Crispin R. Dass, Sally Tran |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Bone Regeneration Bone Morphogenetic Protein 2 Pharmaceutical Science Healing time Bone morphogenetic protein Bone morphogenetic protein 2 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta medicine Animals Humans Orthopedic Procedures Carrier type Adverse effect Intensive care medicine Pharmacology Tissue Engineering business.industry Recombinant Proteins Spinal surgery Surgery 030104 developmental biology Orthopedic surgery Bone Diseases business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Pharmacy and Pharmacology. 68:139-147 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/jphp.12506 |
| Popis: | ObjectivesBone morphogenetic proteins (BMPs), more specifically BMP-2, are being increasingly used in orthopaedic surgery due to advanced research into osteoinductive factors that may enhance and improve bone therapy. There are many areas in therapy that BMP-2 is being applied to, including dental treatment, open tibial fractures, cancer and spinal surgery. Within these areas of treatment, there are many reports of successes and pitfalls. This review explores the use of BMP-2 and its successes, pitfalls and future prospects in bone therapy.MethodsThe PubMed database was consulted to compile this review.Key findingsWith successes in therapy, there were descriptions of a more rapid healing time with no signs of rejection or infection attributed to BMP-2 treatment. Pitfalls included BMP-2 ‘off-label’ use, which lead to various adverse effects.ConclusionsOur search highlighted that optimising treatment with BMP-2 is a direction that many researchers are exploring, with areas of current research interest including concentration and dose of BMP-2, carrier type and delivery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text