Epithelial-mesenchymal transition during extravillous trophoblast differentiation
| Autor: | Bill Kalionis, Martin Knöfler, Maria I Kokkinos, Hannah Ee Juen Yong, Jürgen Pollheimer, Padma Murthi, Jessica E. Davies |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition Cellular differentiation Placenta Biology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Pre-Eclampsia Pregnancy medicine Humans Epithelial–mesenchymal transition reproductive and urinary physiology 030219 obstetrics & reproductive medicine Fetal Growth Retardation Cadherin Cell adhesion molecule Trophoblast Placentation Cell Differentiation Cell Biology Cell biology Trophoblasts 030104 developmental biology medicine.anatomical_structure Immunology embryonic structures Female Cytotrophoblasts Research Paper |
| Zdroj: | Cell adhesionmigration. 10(3) |
| ISSN: | 1933-6926 |
| Popis: | A successful pregnancy depends on the intricate and timely interactions of maternal and fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular transition from an epithelial to mesenchymal phenotype. Villous cytotrophoblasts undergo a partial epithelial to mesenchymal transition (EMT) when differentiating into extravillous cytotrophoblasts and gain the capacity to migrate and invade. This review summarizes our current knowledge regarding known regulators of EMT in the human placenta, including the inducers of EMT, upstream transcription factors that control EMT and the downstream effectors, cell adhesion molecules and their differential expression and functions in pregnancy pathologies, preeclampsia (PE) and fetal growth restriction (FGR). The review also describes the research strategies that were used for the identification of the functional role of EMT targets in vitro. A better understanding of molecular pathways driven by placental EMT and further elucidation of signaling pathways underlying the developmental programs may offer novel strategies of targeted therapy for improving feto-placental growth in placental pathologies including PE and FGR. |
| Databáze: | OpenAIRE |
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