Ruxolitinib-conjugated gold nanoparticles for topical administration: An alternative for treating alopecia?
| Autor: | Sonia Selicean, Daiana Cosmina Temian, Sanda Boca, Wilhelm-Thomas Micu, Cristian Berce, Vlad Moisoiu, Ioana Berindan-Neagoe, Simion Astilean, Grigore-Aristide Gafencu, Cornelia Braicu, Ciprian Tomuleasa, Bobe Petrushev, Laura Pop, Ancuta Jurj |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug Ruxolitinib media_common.quotation_subject Administration Topical Skin Absorption Metal Nanoparticles 02 engineering and technology Dermatology Pharmacology 03 medical and health sciences Pharmacokinetics Microscopy Electron Transmission Nitriles medicine Animals Humans Protein Kinase Inhibitors media_common Skin business.industry Alopecia General Medicine Models Theoretical 021001 nanoscience & nanotechnology medicine.disease Lipids 030104 developmental biology Pyrimidines Colloidal gold Pharmacodynamics Alopecia universalis Nanomedicine Pyrazoles Interdisciplinary Communication Gold 0210 nano-technology Janus kinase business Porosity medicine.drug |
| Zdroj: | Medical hypotheses. 109 |
| ISSN: | 1532-2777 |
| Popis: | Alopecia is a dermatological condition for which Janus kinase (JAK) inhibitors have recently emerged as potential therapy options, but with limited practical use because of the systemic side effects. The topical use of Ruxolitinib in alopecia universalis has been demonstrated, but little is known about the pharmacodynamics and pharmacokinetics of this way of administration. Nanomedicine provides improved therapeutics. In the current paper we present preliminary data regarding the potential use of Ruxolitinib-conjugated gold nanoparticles (GNPs) in dermatological conditions, as GNPs have been proven to have a reduced absorption rate into the systemic blood flow for cutaneous administration. Internalization of the newly formed bioconjugate was assessed by electron microscopy and the functional effects of the drug were investigated by cell counting, flow cytometry and western blotting. Our data show that gold nanoparticles conjugated with Ruxolitinib inhibit the proliferation of fibroblasts by inhibiting JAK2 protein. Ruxolitinib carried by gold nanoparticles alters the proliferation of human fibroblasts, which is of great clinical importance as it can be readily administered on the skin with minimal risk of systemic side effects. |
| Databáze: | OpenAIRE |
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