β-Cell Function in Pancreatic Adenocarcinoma
| Autor: | Alessandro P. Burlina, G. Del Favero, F. D’Angeli, Daniela Basso, Mario Plebani, M.P. Panozzo, C Ferrara, G Briani, Paola Fogar, Tamara Meggiato |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Endocrinology Diabetes and Metabolism Adenocarcinoma Glucagon Endocrinology Internal medicine Pancreatic cancer Diabetes mellitus Internal Medicine Humans Medicine Pancreatic hormone C-Peptide Hepatology business.industry Middle Aged medicine.disease Pancreatic Neoplasms medicine.anatomical_structure Female CA19-9 business Pancreas |
| Zdroj: | Pancreas. 9:332-335 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-199405000-00008 |
| Popis: | To evaluate beta-cell function in patients with pancreatic cancer, the glucagon stimulation test was performed in seven patients with pancreatic adenocarcinoma, seven patients with type I diabetes mellitus, seven patients with type II diabetes mellitus, and in seven healthy controls. C-peptide serum levels were determined before and after a 1-mg i.v. glucagon injection. Basal C-peptide values were normal or slightly increased in pancreatic cancer and type II diabetic patients and low in type I diabetic patients. Following glucagon stimulation, no significant increase was observed in C-peptide values of type I diabetics and pancreatic cancer patients, whereas significant increases occurred in controls and type II diabetics. It is concluded that the altered beta-cell function found in pancreatic cancer patients may lead to hyperglycemia, which is frequently associated with this tumor type. |
| Databáze: | OpenAIRE |
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