Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI

Autor: Axel Wetter, Marcus Ruhlmann, Christoph Bergmann, Benedikt M. Schaarschmidt, Philipp Heusch, Michael Forsting, Verena Ruhlmann, Christian Buchbender, Gerald Antoch, Marc Schlamann
Rok vydání: 2015
Předmět:
Male
medicine.medical_specialty
Medizin
Multimodal Imaging
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Recurrence
medicine
Humans
Radiology
Nuclear Medicine and imaging
Basal cell
Head and neck
neoplasms
Aged
Neoplasm Staging
Retrospective Studies
Multimodal imaging
PET-CT
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Mr imaging
Head and neck squamous-cell carcinoma
carbohydrates (lipids)
stomatognathic diseases
Head and Neck Neoplasms
Positron emission tomography
Positron-Emission Tomography
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Female
Radiology
Tomography
X-Ray Computed
Nuclear medicine
business
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging. 43:92-102
ISSN: 1619-7089
1619-7070
Popis: To evaluate the accuracy of integrated (18)F-FDG PET/MR imaging for locoregional tumour evaluation compared to (18)F-FDG PET/CT and MR imaging in initial tumour and recurrence diagnosis in histopathologically confirmed head and neck squamous cell carcinoma (HNSCC).(18)F-FDG PET/CT and integrated (18)F-FDG PET/MR imaging were performed for initial tumour staging or recurrence diagnosis in 25 patients with HNSCC. MR, fused (18)F-FDG PET/CT and fused (18)F-FDG PET/MR images were analysed by two independent readers in separate sessions in random order. In initial tumour staging, T and N staging was performed while individual lesions were analysed in patients with suspected cancer recurrence. In T and N staging, histopathological results after tumour resection served as the reference standard while histopathological sampling as well as cross-sectional and clinical follow-up were accepted in cancer recurrence diagnosis. The diagnostic accuracy of each modality was calculated separately for T and N staging as well as for tumour recurrence, and compared using McNemar's test. Values of p0.017 were considered statistically significant after Bonferroni correction.In 12 patients undergoing (18)F-FDG PET/CT and (18)F-FDG PET/MR for initial tumour staging, T staging was accurate in 50 % with MRI, in 59 % with PET/CT and in 75 % with PET/MR while N staging was accurate in 75 % with MRI, in 77 % with PET/CT and in 71 % with PET/MR in relation to the reference standard. No significant differences were observed in T and N staging among the three modalities (p 0.017). In 13 patients undergoing hybrid imaging for cancer recurrence diagnosis, diagnostic accuracy was 57 % with MRI and in 72 % with (18)F-FDG PET/CT and (18)F-FDG PET/MR, respectively. Again, no significant differences were found among the three modalities (p 0.017).In this initial study, no significant differences were found among (18)F-FDG PET/MR, (18)F-FDG PET/CT and MRI in local tumour staging and cancer recurrence diagnosis.
Databáze: OpenAIRE
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