Gender differences in the activities of aspirin-esterases in rat tissues
| Autor: | M.A.C. Benedito |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
sex differences
Male Sex Differentiation Physiology Kidney Biochemistry chemistry.chemical_compound Adrenal Glands General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 chemistry.chemical_classification lcsh:R5-920 Aspirin biology General Neuroscience Brain General Medicine Salicylates medicine.anatomical_structure Liver Female lcsh:Medicine (General) medicine.drug medicine.medical_specialty Immunology Biophysics liver Sex Factors Estrus Internal medicine medicine Animals Rats Wistar aspirin-esterases Estrous cycle Sexual differentiation Significant difference Cell Biology Enzyme assay Rats rats Endocrinology Enzyme lcsh:Biology (General) chemistry biology.protein serum Carboxylic Ester Hydrolases Salicylic acid |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 31, Issue: 9, Pages: 1113-1118, Published: SEP 1998 Brazilian Journal of Medical and Biological Research v.31 n.9 1998 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 31, Iss 9, Pp 1113-1118 (1998) |
| ISSN: | 0100-879X |
| Popis: | The activities of aspirin (acetylsalicylic acid)-esterases were measured in several tissues (liver, kidney, adrenal glands, brain and serum) from adult male and female Wistar rats. In males, both aspirin-esterase I (assayed at pH 5.5) and II (assayed at pH 7.4) activities were higher in liver homogenates when compared to females (aspirin-esterase I: males 48.9 +/- 4.8 (N = 8) and females 29.3 +/- 4.2 (N = 8) nmol of salicylic acid formed min-1 mg protein-1; aspirin-esterase II: males 41.4 +/- 4.1 (N = 8) and females 26.1 +/- 4.5 (N = 8) nmol of salicylic acid formed min-1 mg protein-1, P < 0.001). In serum, enzyme activity was higher in females than in males (aspirin-esterase I: males 0.85 +/- 0.06 (N = 6) and females 1.18 +/- 0.11 (N = 6) nmol of salicylic acid formed min-1 mg protein-1, aspirin-esterase II: males 1.03 +/- 0.13 (N = 6) and females 1.34 +/- 0.11 (N = 6) nmol of salicylic acid formed min-1 mg protein-1, P < 0.001). In the other tissues assayed, no statistically significant difference between males and females was found. There were no statistically significant differences when the enzymes were assayed in different phases of the estrous cycle in liver and serum. These results show that the differences in aspirin-esterase activity observed between males and females are not due to the estrous cycle. The gender difference obtained in our study may indicate an involvement of gonadal hormones in the control of the hydrolysis of aspirin. This possibility is currently under investigation. |
| Databáze: | OpenAIRE |
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