β-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans
Autor: | Ru-Jun Zhang, Ruonan Ning, Di Wu, Lei Gao, Di Chen, Jianfeng Lan, Wei-Min Zhao |
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Rok vydání: | 2016 |
Předmět: |
Pharmacology
Nematode caenorhabditis elegans Molecular Structure 010405 organic chemistry Organic Chemistry Longevity Pharmaceutical Science Positive control Celastrus Biology 01 natural sciences Celastrus monospermus 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Drug Discovery Botany Seeds Molecular Medicine Animals Caenorhabditis elegans Sesquiterpenes |
Zdroj: | Journal of natural products. 79(12) |
ISSN: | 1520-6025 |
Popis: | Seventeen β-dihydroagarofuran-type sesquiterpenes were isolated from the seeds of Celastrus monospermus, and, among them, 15 (1–15) were identified as new natural products. Nine isolates were evaluated for their lifespan-extending effect using the standard model animal nematode Caenorhabditis elegans. As a result, all of the tested compounds prolonged the lifespan of C. elegans when compared to the blank control group (p < 0.0001). Among them, celaspermin E (5) extended the average lifespan and maximum lifespan of C. elegans, with effects similar to those of rapamycin, a positive control that has been found experimentally to delay the aging process of yeasts, worms, fruit flies, and mice. |
Databáze: | OpenAIRE |
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