Expression of Fbp2, a Newly Discovered Constituent of Memory Formation Mechanisms, Is Regulated by Astrocyte–Neuron Crosstalk
| Autor: | Agnieszka Gizak, Dariusz Rakus, Dominika Drulis-Fajdasz, Przemysław Duda, Olga Wójcicka, Daria Hajka |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell type
Cell Communication Hif1α Article Gene Expression Regulation Enzymologic Catalysis lcsh:Chemistry Inorganic Chemistry Mice Paracrine signalling Memory Fbp2 medicine Animals Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy Neurons Mice Inbred BALB C c-Fos Neuronal Plasticity Chemistry Organic Chemistry Long-term potentiation General Medicine Extracellular vesicle astrocyte–neuron crosstalk Fructose-Bisphosphatase Computer Science Applications Cell biology Crosstalk (biology) medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 nervous system Astrocytes Synaptic plasticity Neuron Energy Metabolism extracellular vesicles Signal Transduction Astrocyte |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 18 International Journal of Molecular Sciences, Vol 21, Iss 6903, p 6903 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21186903 |
| Popis: | Fbp2 (muscle isozyme of fructose 1,6-bisphosphatase) is a glyconeogenesis-regulating enzyme and a multifunctional protein indispensable for long-term potentiation (LTP) formation in the hippocampus. Here, we present evidence that expression of Fbp2 in murine hippocampal cell cultures is regulated by crosstalk between neurons and astrocytes. Co-culturing of the two cell types results in a decrease in Fbp2 expression in astrocytes, and its simultaneous increase in neurons, as compared to monocultures. These changes are regulated by paracrine signaling using extracellular vesicle (EV)-packed factors released to the culture medium. It is well accepted that astrocyte&ndash neuron metabolic crosstalk plays a crucial role in shaping neuronal function, and recently we have suggested that Fbp2 is a hub linking neuronal signaling with redox and/or energetic state of brain during the formation of memory traces. Thus, our present results emphasize the importance of astrocyte&ndash neuron crosstalk in the regulation of the cells&rsquo metabolism and synaptic plasticity, and bring us one step closer to a mechanistic understanding of the role of Fbp2 in these processes. |
| Databáze: | OpenAIRE |
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