Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

Autor: Roshan Cools, Romain Ligneul, Anne S. Berry, William J. Jagust, Lieneke Janssen, Femke de Boer, Ruth J. van Holst, Guillaume Sescousse, Marcel J.R. Janssen
Přispěvatelé: Leerstoel Ridder, Stress and self-regulation, ANS - Compulsivity, Impulsivity & Attention, Adult Psychiatry, APH - Mental Health
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Dopamine
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
Eye
0302 clinical medicine
Receptors
[F-18]DOPA
Psychology
Neurosystems
General Neuroscience
05 social sciences
Cognition
Middle Aged
proxy measure
Mental Health
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
Neurological
Biomedical Imaging
Cognitive Sciences
medicine.drug
Adult
[18F]DOPA
Dopamine synthesis
Neuroscience(all)
Positive correlation
050105 experimental psychology
03 medical and health sciences
Neurochemical
Clinical Research
Dopamine receptor D2
Dopamine D2
medicine
Humans
0501 psychology and cognitive sciences
Pathological
[F]DOPA
Neurology & Neurosurgery
Blinking
Receptors
Dopamine D2
business.industry
Neurosciences
Corpus Striatum
PET
Positron-Emission Tomography
Gambling
Eye blink
business
170 000 Motivational & Cognitive Control
eye blink rate
Neuroscience
030217 neurology & neurosurgery
Zdroj: European Journal of Neuroscience, 47, 1081-1086
The European Journal of Neuroscience
The European journal of neuroscience, vol 47, iss 9
European Journal of Neuroscience, 47, 9, pp. 1081-1086
European Journal of Neuroscience, 47(9), 1081. Blackwell Publishing Ltd
European journal of neuroscience, 47(9), 1081-1086. Wiley-Blackwell
Sescousse, G; Ligneul, R; van Holst, RJ; Janssen, LK; de Boer, F; Janssen, M; et al.(2018). Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation. European Journal of Neuroscience, 47(9), 1081-1086. doi: 10.1111/ejn.13895. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/36s8b19q
European Journal of Neuroscience
ISSN: 0953-816X
DOI: 10.1101/215178
Popis: Contains fulltext : 193467.pdf (Publisher’s version ) (Open Access) Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioral proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of dopamine function in humans. In order to fill this gap, we measured sEBR and striatal dopamine synthesis capacity using [(18) F]DOPA PET in 20 participants (9 healthy individuals and 11 pathological gamblers). Our results, based on frequentist and Bayesian statistics, as well as region-of-interest and voxel-wise analyses, argue against a positive relationship between sEBR and striatal dopamine synthesis capacity. They show that, if anything, the evidence is in favor of a negative relationship. These results, which complement findings from a recent study that failed to observe a relationship between sEBR and dopamine D2 receptor availability, suggest that caution and nuance are warranted when interpreting sEBR in terms of a proxy measure of striatal dopamine. This article is protected by copyright. All rights reserved. 6 p.
Databáze: OpenAIRE
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