THE IMPORTANCE OF H-Y INCOMPATIBILITY IN HUMAN ORGAN TRANSPLANTATION
| Autor: | B.A. Bradley, J.J. van Rood, Els Goulmy, Lansbergen Q |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Cytotoxicity
Immunologic Male medicine.medical_specialty Blood transfusion medicine.medical_treatment Priming (immunology) Human leukocyte antigen Organ transplantation Epitopes Antigen HLA Antigens Y Chromosome medicine Humans Transplantation Homologous Blood Transfusion Lymphocytes Kidney transplantation Bone Marrow Transplantation Transplantation Sex Chromosomes biology business.industry Graft Survival Anemia Aplastic medicine.disease Kidney Transplantation Killer Cells Natural Immunology biology.protein Female Antibody business Immunologic Memory |
| Zdroj: | Transplantation. 25:315-319 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-197806000-00007 |
| Popis: | SUMMARY As an extension of our first observation in which the peripheral blood lymphocytes of an aplastic amaemia patient with a transplant were able to show HLA-restricted H-Y killing in a cell-mediated lympholysis assay, we report here a second case showing exactly the same phenomenon. SUMMARY A multitransfused woman suffering from aplastic anaemia was shown to have in vitro killing after priming her lymphocytes with her HLA-identical brother. This killing was directed to all male target cells carrying the HLA-A2 antigen. Marginally, killing was also directed to some HLA-A2 female target cells, but this was at a considerably lower level than that directed to male cells. The level of HLA-restricted H-Y killing declined with time. However, it was possible to reactivate the H-Y specific killing by in vitro stimulation with lymphocytes from an HLA-A, -B, and -C-identical, but HLA-D-different male donor. That these findings could be relevant for renal transplantation was supported by renal allograft survival data obtained at 2 years after transplantation. Male allografts from HLA-A2-positive donors in A2-positive females survived for a significantly shorter time than non-A2 male kidneys in non-A2 female recipients. This was only apparent in recipients who produced antileukocyte antibodies. |
| Databáze: | OpenAIRE |
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