Analyzing Relative Blood Flow Speeds in Choroidal Neovascularization Using Variable Interscan Time Analysis OCT Angiography
| Autor: | Rebhun, Carl B., Moult, Eric Michael, Ploner, Stefan B, Neto, Carlos Moreira, Alibhai, A. Yasin, Schottenhamml, Julia Jennifer, Lee, ByungKun, Choi, WooJhon, Rifai, Fareed A., Tam, Mary W., Husvogt, Lennart Alexander, Baumal, Caroline R., Witkin, Andre J., Maier, Andreas, Rosenfeld, Philip J., Duker, Jay S., Fujimoto, James G., Waheed, Nadia K., Fujimoto, James G |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Research Laboratory of Electronics, Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
genetic structures Hemodynamics 01 natural sciences Article 010309 optics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Text mining Ophthalmology 0103 physical sciences medicine business.industry Blood flow Macular degeneration medicine.disease Trunk eye diseases Peripheral Vascular endothelial growth factor Choroidal neovascularization chemistry 030221 ophthalmology & optometry sense organs medicine.symptom business |
| Zdroj: | PMC |
| Popis: | Purpose Longitudinally visualizing relative blood flow speeds within choroidal neovascularization (CNV) may provide valuable information regarding the evolution of CNV and the response to vascular endothelial growth factor (VEGF) inhibitors. Design Retrospective, longitudinal case series conducted at the New England Eye Center. Participants Patients with either treatment-naive or previously treated CNV secondary to neovascular age-related macular degeneration. Methods Optical coherence tomography angiography (OCTA) was performed using a 400-kHz, 1050-nm swept-source OCT system with a 5-repeat B-scan protocol. Variable interscan time analysis (VISTA) was used to compute relative flow speeds from pairs of B-scans having 1.5- and 3.0-ms separations; VISTA signals then were mapped to a color space for display. Main Outcome Measures Quantitative outcomes included OCTA-based area and volume measurements of CNV at initial and follow-up visits. Qualitative outcomes included VISTA OCTA analysis of relative blood flow speeds, along with analysis of contraction, expansion, densification, and rarefication of CNV. Results Seven eyes of 6 patients (4 women and 2 men) with neovascular age-related macular degeneration were evaluated. Two eyes were treatment naive at the initial visit. Choroidal neovascularization in all eyes at each visit showed relatively higher flow speeds in the trunk, central, and larger vessels and lower flow speed in the small vessels, which generally were located at the periphery of the CNV complex. Overall, the CNV appeared to expand over time despite retention of good visual acuity in all patients. In the treatment-naive patients, slower-flow-speed vessels contracted with treatment, whereas the larger vessels with higher flow speed remained constant. Conclusions Variable interscan time analysis OCTA allows for longitudinal observations of relative blood flow speeds in CNV treated with anti-VEGF intravitreal injections. A common finding in this study is that the main trunk and larger vessels seem to have relatively faster blood flow speeds compared with the lesions' peripheral vasculature. Moreover, an overall growth of chronically treated CNV was seen despite retention of good visual acuity. The VISTA framework may prove useful for developing clinical end points, as well as for studying hemodynamics, disease pathogenesis, and treatment response. |
| Databáze: | OpenAIRE |
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