Impaired Homocysteine Metabolism Associated with High Plasma Interleukin- 17A Levels, a Pro-Atherogenic Marker, in an Endogamous Population of North India
| Autor: | Kallur Nava Saraswathy, Priyanka Garg, Lovejeet Kaur, Pradeep Kumar Ghosh |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Hyperhomocysteinemia Homocysteine Epidemiology Population India Original Report: Cardiovascular Disease and Risk Factors Peripheral blood mononuclear cell 03 medical and health sciences chemistry.chemical_compound Internal medicine Prevalence medicine Humans Vitamin B12 education Methylenetetrahydrofolate Reductase (NADPH2) education.field_of_study biology business.industry Interleukin-17 Forkhead Transcription Factors General Medicine Middle Aged medicine.disease Interleukin-10 Vitamin B 12 030104 developmental biology Endocrinology chemistry Population Surveillance Methylenetetrahydrofolate reductase Leukocytes Mononuclear biology.protein Female Interleukin 17 Sample collection business Biomarkers |
| Zdroj: | Ethnicity & Disease. 28:525-530 |
| ISSN: | 1945-0826 1049-510X |
| DOI: | 10.18865/ed.28.4.525 |
| Popis: | Background: Impaired homocysteine metabolism (IHM; hyperhomocysteinemia) has been linked with many complex disorders like cardiovascular diseases and immunological disturbances. However, studies understanding IHM in light of pro- and anti-atherogeneic markers like Interleukin-17A & -10 (IL-17A & IL-10) and Forkhead box p3 (Foxp3, a master transcription factor) are scarce.Aim: In our present study, we aimed to understand the relation of IHM with plasma IL-17A and IL-10 levels and Foxp3 mRNA expression in peripheral blood mononuclear cells (PBMCs) from an endogamous population (Jats of Haryana, North India) with high prevalence of IHM without the concurrence of significant adverse cardiovascular outcomes.Methods: Forty (40) clinically healthy individuals, unrelated up to first cousins, were recruited and were subjected to demographic, physiological and anthropometric profiling, followed by intravenous blood sample collection (fasting) and lipid profiling. Plasma homocysteine levels were estimated and individuals with homocysteine levels ≥ 15umol/L and |
| Databáze: | OpenAIRE |
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