SYNTHESIS OF 5-(PYRIDINYL AND PYRIDINIUMYL)-2′-DEOXYURIDINE NUCLEOSIDES: REVERSIBLE ELECTRON TRAPS FOR DNA

Autor:	Thomas L. Netzel, Samir T. Gaballah
Rok vydání:	2002
Předmět:	Pyridines Stereochemistry Nucleosides DNA General Medicine Electron Oligonucleotide synthesis Cleavage (embryo) Combinatorial chemistry Deoxyuridine Biochemistry Electron transport chain Electron Transport Structure-Activity Relationship chemistry.chemical_compound Organophosphorus Compounds chemistry Nucleic acid Genetics Molecular Medicine Hydrogenation Conjugate
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 21:681-694
ISSN:	1532-2335 1525-7770
Popis:	The desire to produce reversible electron traps for direct, room temperature studies of excess electron transport in DNA duplexes and hairpins motivated our efforts first to link pyridines to 2′-deoxyuridine (pyridinyl-dU) and then to convert these new conjugates into pyridiniumyl-dU nucleosides. Base sensitivity studies presented here rule out general use of bipyridinediiumyl compounds, but show that pyridiniumyl compounds are suitable for use under the strand cleavage and base deprotection procedures required for automated solid-phase oligonucleotide synthesis. This paper presents the synthesis of four 5′-O-DMT-protected 5-(N-methylpyridiniumyl)-dU conjugates using either ethynyl or ethylenyl linkers to join the pyridiniumyl and dU subunits.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1293108ec7b9d34c61b335aa755239a7 https://doi.org/10.1081/ncn-120015725 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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