Complications Associated With the Use of Recombinant Human Bone Morphogenic Protein–2 in Ridge Augmentation: A Case Report
| Autor: | Charles L. Palin, Praveen Gajendrareddy, Saba M. Khan, Whitney D. Weiner, Panagiotis Dragonas |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Bone Regeneration Maxillary sinus Bone Morphogenetic Protein 2 Dentistry Dehiscence 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta medicine Humans Bone regeneration Dental Implants Augmentation procedure business.industry Regeneration (biology) Dental Implantation Endosseous Alveolar Ridge Augmentation 030206 dentistry Recombinant Proteins Resorption Surgery medicine.anatomical_structure 030220 oncology & carcinogenesis Bone Morphogenetic Proteins Bone maturation Oral Surgery business Complication |
| Zdroj: | Journal of Oral Implantology. 43:351-359 |
| ISSN: | 1548-1336 0160-6972 |
| DOI: | 10.1563/aaid-joi-d-17-00101 |
| Popis: | This case report aims to describe in detail a complication associated with resorption of regenerated bone following implant placement and ridge augmentation using recombinant human bone morphogenic protein–2 (rhBMP-2) in combination with allograft and xenograft. Bilateral maxillary sinus and ridge augmentation procedures were completed using rhBMP-2 combined with allograft and xenograft. Five months later, significant bone augmentation was achieved, which allowed for the placement of 4 implants. Upon stage 2 surgery, significant dehiscence was noted in all implants. Treatment steps to address this complication included implant removal, guided bone regeneration with xenograft only, and placement of new implants followed by soft-tissue grafting. At the time of publication, this patient is status 1½ years post case completion with maintenance of therapy outcomes. Off-label use of rhBMP-2 has gained significant acceptance in implant dentistry. However, there is limited evidence regarding the bone maturation process when rhBMP-2 is combined with other biomaterials. More research may be needed regarding the timing and process of bone healing in the presence of rhBMP-2, in an effort to avoid surgical complications. |
| Databáze: | OpenAIRE |
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