Serum zinc, senile plaques, and neurofibrillary tangles
| Autor: | Christine L. Tully, William R. Markesbery, David A. Snowdon |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Aging
Pathology medicine.medical_specialty chemistry.chemical_element Zinc Central nervous system disease Degenerative disease Alzheimer Disease medicine Amyloid precursor protein Humans Longitudinal Studies Senile plaques Aged Aged 80 and over biology business.industry General Neuroscience Catholicism Neurofibrillary Tangles Neurofibrillary tangle medicine.disease Nun Study chemistry Linear Models biology.protein Female Alzheimer's disease business |
| Zdroj: | NeuroReport. 6:2105-2108 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199511000-00002 |
| Popis: | Zinc appears to have a role in binding amyloid precursor protein in vitro, but it is not known whether zinc plays a role in senile plaque formation in vivo in humans. Serum zinc concentrations were available from 12 sisters who died in the Nun Study, a longitudinal study of aging and Alzheimer's disease. Fasting serum zinc concentrations, determined approximately 1 year before death, showed moderate to strong negative correlations with senile plaque counts in seven brain regions. In all brain regions combined, the age-adjusted negative correlations with serum zinc were statistically significant for total senile plaques and diffuse plaques, and suggestive for neuritic plaques. Thus serum zinc in the normal range may be associated with low senile plaque counts in the elderly. |
| Databáze: | OpenAIRE |
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