Individual reference ranges of CA 15-3, MCA and CEA in recurrence of breast cancer
| Autor: | W. Deschner, M. M. Müller, A. Griesmacher, R. Beer, W. G. E. Hölzel |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Clinical Biochemistry CA 15-3 Diagnostic Specificity Breast Neoplasms Sensitivity and Specificity Breast cancer Carcinoembryonic antigen Recurrence Reference Values Medicine Humans Antigens Tumor-Associated Carbohydrate Volume concentration Aged biology business.industry General Medicine Middle Aged medicine.disease Carcinoembryonic Antigen Clinical evidence Reference values biology.protein Female business Nuclear medicine |
| Zdroj: | Scandinavian journal of clinical and laboratory investigation. Supplementum. 221 |
| ISSN: | 0085-591X |
| Popis: | The long-term intra-individual variation of the title tumour markers was studied in the group of 33 patients which developed no relapse. The average biological intra-individual CV was 11.2% for CA 15-3 and 14.9% for MCA whereas those of CEA strongly depended on the concentration. The intra-individual standard deviation of CEA was independent of concentration and amounted to 0.23 g/L. Individual reference ranges the analytes were much smaller than the group reference ranges. Individual reference limits were calculated on the basis of the average intra-individual variation. In 21 of the 22 patients who developed recurrence during the follow-up period, individual reference limits of CA 15-3 and/or CEA were exceeded 1 to 31 months (median 10 months) before clinical evidence (diagnostic sensitivity 95%). Group reference limits were exceeded only in 13 patients (diagnostic sensitivity 60%) and occurring later. The diagnostic specificity was 97%. MCA did not provide additional information. The combination of CA 15-3 and CEA is an excellent for detection and exclusion of recurrence in the follow-up of breast cancer patients if decision-making is based on individual reference limits. Improvement of the long-term analytical quality of the tumour marker assays, particularly in the low concentration range is necessary. |
| Databáze: | OpenAIRE |
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